Results 61 to 70 of about 841,554 (262)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Association between serial changes in serum C-reactive protein levels and mortality among patients with pleural empyema: a database research

BMC Pulmonary Medicine
Background Although previous studies have evaluated C-reactive protein (CRP) as a diagnostic marker for pleural empyema, the prognostic value of baseline and serial CRP measurements has not been adequately assessed.
Akihiro Shiroshita, Masafumi Takeshita, Teruaki Nishiuma, Tomoaki Ota, Yuki Kataoka   +4 more
doaj   +1 more source

Narrow-Band Imaging versus Magnifying Chromoendoscopy for the Diagnosis of Early Colorectal Cancer Invasion Depth: Systematic Review and Meta-Analysis

Endoscopy International Open
Background and study aim Optical assessment of deep submucosal invasion (T1b) in T1 colorectal cancer (CRC) is critical for selecting endoscopic versus surgical management.
Tomoyuki Nishimura, Kareem Khalaf, Yuki Kataoka, Jun Watanabe, Yuhong Yuan, Tommy Rizkala, Nana Hayashi, Natalia Casuada Calo, Gary May, Jeffrey D. Mosko   +9 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Assessing Evidence Quality for Endovascular Arteriovenous Fistulas

Kidney Medicine, 2022
Yoshinosuke Shimamura, MD, MPH, Yasutaka Kuniyoshi, MD, PhD, Yasushi Tsujimoto, MD, MPH   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Longitudinal changes in KL6 levels predict acute exacerbation in fibrotic interstitial lung disease

Scientific Reports
Krebs von den Lungen-6 (KL-6) levels are potentially indicative markers of prospective acute exacerbation (AE) in interstitial lung disease (ILD); however, their longitudinal trends have not been sufficiently investigated.
Akihiro Shiroshita, Keisuke Anan, Chigusa Shirakawa, Hiroshi Shiba, Nobuyuki Yajima   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source