Results 91 to 100 of about 26,947 (271)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A web-enabled, school-based intervention for bullying prevention (LINKlusive): a cluster randomised trialResearch in context

EClinicalMedicine
Summary: Background: There is a need for more sustainable interventions and for assessing the effectiveness of school-based universal anti-bullying programmes in vulnerable populations.
Celso Arango, Javier Martín-Babarro, Renzo Abregú-Crespo, Miguel Á. Huete-Diego, María Alvariño-Piqueras, Isabel Serrano-Marugán, Covadonga M. Díaz-Caneja   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Accelerators to reduce violence, HIV risk, and early pregnancy among adolescents and young people in Namibia: A cross-sectional analysis of the Violence Against Children & Youth Survey.

PLOS Global Public Health
Our study applied the INSPIRE Framework - the WHO's 2016 technical package of evidence-based interventions for addressing violence against children - to identify accelerators for youth in Namibia.
Madison T Little, Lucas Hertzog, William E Rudgard, Elona Toska, Boladé Banougnin, Rachel Yates, David Chipanta, Francis B Annor, Laura Chiang, Lucie Cluver   +9 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Protecting against school-based victimisation: the role of children's friendship [PDF]

, 2015
Given the detrimental short- and long-term effects of peer-victimisation (Hawker & Boulton, 2000), it is not surprising that bullying has become a central topic for multiple parties; including stake-holders, the media, educators, and researchers.
Betts, LR, Gardner, SE
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Predicting cyberbullying victimisation in emerging markets and developing countries using the Global School-Based Health Survey

Machine Learning with Applications
Objectives: This study aimed to identify predictors of cyberbullying victimisation among adolescents and develop predictive models to support early intervention strategies.
Paulo Ricardo Vieira Braga, Katie Rose Tyrrell   +1 more
doaj   +1 more source

The sustainable delivery of sexual violence prevention education in schools [PDF]

, 2015
Sexual violence is a crime that cannot be ignored: it causes our communities significant consequences including heavy economic costs, and evidence of its effects can be seen in our criminal justice system, public health system, Accident Compensation ...
Good, G, Julich, SJ, Oak, E, Terrell, J
core   +2 more sources

Preventing Domestic Abuse for Children and Young People (PEACH): A Mixed Knowledge Scoping Review [PDF]

, 2015
Background: A range of interventions that aim to prevent domestic abuse has been developed for children and young people in the general population. While these have been widely implemented, few have been rigorously evaluated. This study aimed to discover
Bailey, Sue, Downe, Soo, Ellis, Jane, Farrelly, Nicola, Hollinghurst, Sandra, Stanley, Nicky   +5 more
core   +2 more sources