Results 41 to 50 of about 604,275 (298)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Exchange rate regimes and global cocoa trade: to float or to peg?

open access: yesCogent Economics & Finance, 2020
The effectiveness of different exchange rate systems continues to attract the attention of many scholars, however, most discussions on exchange rate regimes have focused on how the phenomenon affects economic growth, economic stability, financial crises,
Bismark Addai   +2 more
doaj   +1 more source

Effect of Additional Polyethylene Glycol and Citric Acid on Characteristics of NiMo/g-Al2O3 Catalyst in Light Cycle Gas Oil Hydrodesulfurisation

open access: yesBulletin of Chemical Reaction Engineering & Catalysis, 2023
Sulfur is an impurity in diesel that causes low product quality and environmental pollution. Therefore, a catalyst is needed in the profound hydrodesulfurization (HDS) reaction to produce diesel fuel with low sulfur content.
Dede Sukandar   +3 more
doaj   +1 more source

Pastiche [PDF]

open access: yes, 2014
The term "pastiche" originally means a "pasty" or "pie" dish containing several different ingredients. It has come to be used synonymously with a variety of terms whose meanings are rarely fixed with clarity: parody, montage, quotation, allusion, irony ...
Weiser, Peg Zeglin Brand
core  

ST/STIS Spectroscopy of the White Dwarfs in the Short-Period Dwarf Novae LL And and EF Peg [PDF]

open access: yes, 2002
We present new HST/STIS observations of the short-period dwarf novae LL And and EF Peg during deep quiescence. We fit stellar models to the UV spectra and use optical and IR observations to determine the physical parameters of the whitedwarfs in the ...
Boris T. Gansicke   +6 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Effect of Different Molecular Weight and Concentration of Polyethylene Glycol (PEG) on Tensile and Morphology of Sago Starch Film

open access: yesASM Science Journal, 2021
Sago starch is a seasonal based plantation and widely found in Asia country. Its application mainly in cooking such as biscuits and as a thickener in jellies. To further utilize its application, bioplastic from sago starch was developed.
Norzita Yacob
doaj   +1 more source

Field Conservation of Archaeological Textile Artefacts as a Preparatory Stage For Laboratory Restoration

open access: yesАрхеология евразийских степей, 2021
Archaeological textile finds are rare due to their poor preservation state. Unearthed and recorded textile artefacts or their fragments often simply do not reach the restoration stage as they are destroyed during burial cleaning, removal from the soil ...
Olga L. Shvets   +2 more
doaj   +1 more source

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