Results 41 to 50 of about 20,354 (239)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

OPTIMASI PERLAKUAN POLYETHYLENE GLIKOL (PEG) 6000 TERHADAP ISOLASI AGAROSA RUMPUT LAUT Glacilaria sp.

Sains Natural, 2017
Optimation of Polyethylene Glycol (PEG) 6000 Treatment on Isolation of Agarose Seaweeds of Glacilaria sp          Isolation of agarose from seaweeds (Glacilaria sp) had been done in acid, base, and neutral condition by using polyethylene glycol
Siti Martinah, RTM Sutamihardja, Lilis Sugiarti   +2 more
doaj   +1 more source

Breaking the Trade‐Off of Mechanical Robustness and Energy Storage Capacity in Phase Change Materials Through a Molecular Design Strategy of Hard‐Segment‐Anchored/Side‐Chain‐Storage

Advanced Science, EarlyView.
To decouple mechanical robustness and energy storage capacity in phase change materials (PCMs), a series of polyurethane‐based PCMs bearing crystallizable alkyl side chains are synthesized via a hard‐segment‐anchored/side‐chain‐storage molecular design.
Huizhou Luo, Hebo Shi, Jun Zhang, Henghui Deng, Yongyin Zhu, Zehong Chen, Chaoqun Zhang   +6 more
wiley   +1 more source

Effects of Selenium on DNA Methylation and Genomic Instability Induced by Drought Stress in Wheat (Triticum aestivum L.)

Türkiye Tarımsal Araştırmalar Dergisi
The main purpose of the study was to clarify the effect of selenium (Se) on DNA damage and DNA methylation in wheat (Triticum aestivum L.) plants exposed to polyethylene glycol (PEG)-induced drought stress under in vitro tissue culture.
Zehra Şahin, Güleray Ağar, Esma Yiğider, Murat Aydın   +3 more
doaj   +1 more source

Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Advances in Pharmacological and Pharmaceutical Sciences, 2020
The treatment of type II DM involves the use of combination of drugs, especially at the chronic stage. However, the pill burden of this combination therapy combined with swallowing difficulties, occurring at a later stage of DM, has been the major ...
Anteneh Belayneh, Fantahun Molla, Getu Kahsay   +2 more
doaj   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Effects of drought stress on seed germination, growth and physiological traits of dwarf wheats at seedling and maturity stage

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Water deficiency is a major constraint in wheat productivity in arid and semi-arid areas. Height-reducing genes, such as Rht decrease plant height while enhancing yield. However, their benefits in arid environments are poorly understood. We evaluate the
Shan DUAN, Peipei AN, Xiaoyan ZHANG, Xuezhen LIU, Jia ZHANG, Xiaoyu WANG, Lei XING, Julian ZHAO   +7 more
doaj   +1 more source

Multi‐Stimuli Responsive Magneto‐Coacervate Droplets for Selective Molecular Enrichment and Programmable Manipulation

Advanced Science, EarlyView.
ABSTRACT Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical ...
Kailang Liu, Haocheng Ran, Haohui Ou, Peiying Chen, Cheng Qi, Tiantian Kong, Zhou Liu   +6 more
wiley   +1 more source

Drought Stress Tolerance in Wheat Using PEG 6000

This research evaluated the ability of five wheat types—K-9107, HD 2954, Raj-4125, HUW234, and NW-2036—to withstand limited water availability using a lab-based setup with PEG-6000 to mimic dry conditions at an osmotic level of -1.0 bars. As Triticum aestivum plays a key role in India's diet by supplying more than half of the population's energy and ...
KOMAL, KIRTI CHUNDAWAT, NARENDRA MEGHWAL, KARTIK AGRAWAT   +3 more
openaire   +1 more source

Formulation of fenofibrate capsules by dropping method using PEG 6000 and PEG 4000 to enhance solubility

World Journal of Biology Pharmacy and Health Sciences
The primary aim of the study was to enhance the dissolution rate of fenofibrate, a poorly soluble drug classified under BCS class II. To achieve this, solid dispersions were formulated using the dropping method with polyethylene glycol (PEG) 4000 and PEG 6000 at ratios of 1:1 and 1:2.
Gowtham Mandadapu, Prachetha Kolli, Kurra Venkata Gopaiah, Ramya Teja Medarametla, G. Rajesh   +4 more
openaire   +1 more source