Results 271 to 280 of about 6,229,738 (373)

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao, Zhili Wang, Hyoyong Kim, Hui Kong, Junseok Lee, Jacqueline Ziqian Yang, Anmin Wang, Ryan Y. Zhang, Yong Ju, Jina Kim, Bing Feng, Dejun Liu, Yating Zhang, Zhenfang Wang, Yandong Zhang, Shujing Guo, Dekang Gao, James S. Tomlinson, Renjun Pei, Jipeng Wan, Stephen J. Pandol, Myung‐Shin Sim, Sungyong You, Ding Ma, Shaohua Lu, Na Sun, Hsian‐Rong Tseng, Yazhen Zhu   +27 more
wiley   +1 more source

Magnetic nanosheets: from iron oxide nanocubes to polydopamine embedded 2D clusters and their multi-purpose properties.

Nanoscale Horiz
Mandriota G, Avugadda SK, Sadeghi E, Silvestri N, Marotta R, Gavilán H, Olsson U, Giannini C, Tsai YH, Samia ACS, Pellegrino T.   +10 more
europepmc   +1 more source

High‐Speed Hyperspectral Imaging for Near Infrared Fluorescence and Environmental Monitoring

Advanced Science, EarlyView.
This study introduces a fast hyperspectral imaging method in the near‐infrared range (HyperNIR). Combining tunable polarization optics with a phasor‐based approach, HyperNIR captures detailed spectral information with just three images. The applicability is showcased by distinguishing NIR fluorophores that are separated by 5 nm.
Jan Stegemann, Franziska Gröniger, Krisztian Neutsch, Han Li, Benjamin Scott Flavel, Justus Tom Metternich, Luise Erpenbeck, Poul Bering Petersen, Per Niklas Hedde, Sebastian Kruss   +9 more
wiley   +1 more source

Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments. [PDF]

NPJ Biomed Innov
Stealey S, Dharmesh E, Bhagat M, Tyagi AM, Schab A, Hong M, Osbourn D, Abu-Amer Y, Jelliss PA, Zustiak SP.   +9 more
europepmc   +1 more source

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

Novel Tissue-Specific Multifunctionalized Nanotechnological Platform Encapsulating Riluzole Against Motor Neuron Diseases. [PDF]

Int J Nanomedicine
Esteruelas G, Ettcheto M, Haro I, Herrando-Grabulosa M, Gaja-Capdevila N, Gomara MJ, Navarro X, Espina M, Souto EB, Camins A, García ML, Sánchez-López E.   +11 more
europepmc   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Zwitterionic lipid nanoparticles for efficient siRNA delivery and hypercholesterolemia therapy with rational charge self-transformation. [PDF]

Theranostics
Zhao R, Guo J, Liu Z, Zhang Y, Zuo J, Lv S, Li X, Yao W, Zhang X.   +8 more
europepmc   +1 more source

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single‐Cell Secretory and Intracellular Dynamics

Advanced Science, EarlyView.
This study leverages the complementary advantages of label‐free nanoplasmonic biosensing and multichannel fluorescence microscopy to develop a multimodal imaging system for real‐time, spatiotemporal monitoring of cellular activities at the single‐cell level.
Saeid Ansaryan, Yung‐Cheng Chiang, Yen‐Cheng Liu, Patrick Reichenbach, Melita Irving, Hatice Altug   +5 more
wiley   +1 more source

Structural and Biochemical Characterization of a Widespread Enterobacterial Peroxidase Encapsulin

Advanced Science, EarlyView.
Encapsulins are self‐assembling bacterial protein compartments loaded with cargo enzymes. The most abundant encapsulin cargo class are Dye‐decolorizing Peroxidases (DyPs). In this study, we structurally and biochemically characterize a DyP encapsulin found in many enterobacteria.
Natalia C. Ubilla‐Rodriguez, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source