Results 201 to 210 of about 20,314 (255)
Combating small extracellular vesicle-mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides. [PDF]
Signal Transduct Target TherKim CH +17 more
europepmc +1 more source
Site-Specific PEGylation of Therapeutic Proteins [PDF]
International Journal of Molecular Sciences, 2015 The use of proteins as therapeutics has a long history and is becoming ever more common in modern medicine. While the number of protein-based drugs is growing every year, significant problems still remain with their use.
Mark Distefano, Distefano Mark D
exaly +2 more sources
PEGylation in anti-cancer therapy: An overview [PDF]
Asian Journal of Pharmaceutical Sciences, 2016 Advanced drug delivery systems using poly(ethylene glycol) (PEG) is an important development in anti-cancer therapy. PEGylation has the ability to enhance the retention time of the therapeutics like proteins, enzymes small molecular drugs, liposomes and ...
Dey Ratan Kumar +2 more
exaly +2 more sources
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Clinics in Liver Disease, 2003
In summary, pegylated IFNs have a longer half-life, reduced immunogenicity, better pharmacokinetics, and enhanced biological activity when compared with standard IFN. Better adherence rates are feasible because of the once weekly administration of pegylated IFN. The adverse event profile is largely comparable. The improved pharmacokinetics of pegylated
Umaprasanna S, Karnam, K Rajender, Reddy
openaire +2 more sources
In summary, pegylated IFNs have a longer half-life, reduced immunogenicity, better pharmacokinetics, and enhanced biological activity when compared with standard IFN. Better adherence rates are feasible because of the once weekly administration of pegylated IFN. The adverse event profile is largely comparable. The improved pharmacokinetics of pegylated
Umaprasanna S, Karnam, K Rajender, Reddy
openaire +2 more sources
Interaction between PEG lipid and DSPE/DSPC phospholipids: An insight of PEGylation degree and kinetics of de-PEGylation [PDF]
Colloids and Surfaces B: Biointerfaces, 2017 The degree to which liposomes are PEGylated is the feature, which most influences the length of the presence of stealth liposomes in the bloodstream.
Felisa Cilurzo +2 more
exaly +2 more sources
Purification of PEGylated Proteins, with the Example of PEGylated Lysozyme and PEGylated scFv
2014PEGylation is a common and highly accepted possibility for half-life prolongation of proteins by increasing the hydrodynamic size. The chromatographic purification of PEGylated protein, using PEG (poly-ethylene glycol) of different PEG chain lengths, with the example of lysozyme and a scFv, is described in detail here, and helpful suggestions for the ...
Anna, Moosmann +2 more
openaire +2 more sources
Biomacromolecules, 2010
Thermoresponsive oligo(ethylene glycol)-based copolymers were investigated for trypsin conjugation. These copolymers have been synthesized by atom transfer radical polymerization of 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) with oligo(ethylene glycol) methyl ether methacrylate (OEGMA(475), M(n) = 475 g.mol(-1)) at 60 degrees C in the presence of
Zarafshani, Z., Obata, T., Lutz, J.
openaire +3 more sources
Thermoresponsive oligo(ethylene glycol)-based copolymers were investigated for trypsin conjugation. These copolymers have been synthesized by atom transfer radical polymerization of 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) with oligo(ethylene glycol) methyl ether methacrylate (OEGMA(475), M(n) = 475 g.mol(-1)) at 60 degrees C in the presence of
Zarafshani, Z., Obata, T., Lutz, J.
openaire +3 more sources
PEGylation of therapeutic proteins [PDF]
Biotechnology Journal, 2010 AbstractSince the first PEGylated product was approved by the Food and Drug Administration in 1990, PEGylation has been widely used as a post‐production modification methodology for improving biomedical efficacy and physicochemical properties of therapeutic proteins.
Jevsevar, Simona +2 more
exaly +4 more sources
Process for protein PEGylation
Journal of Controlled Release, 2014PEGylation is a versatile drug delivery technique that presents a particularly wide range of conjugation chemistry and polymer structure. The conjugated protein can be tuned to specifically meet the needs of the desired application. In the area of drug delivery this typically means to increase the persistency in the human body without affecting the ...
Massimo Morbidelli
exaly +4 more sources