Results 201 to 210 of about 32,225 (250)
Cationic lipid-based nanoparticles for therapeutic delivery in cancer treatment: physicochemical characteristics, therapeutic cargos, and clinical potential. [PDF]
Appl MicroscBae CS, Ahn T.
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Efficacy of PVX and PEGylated PVX as intratumoral immunotherapy.
Mater AdvMa Y +3 more
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Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte
Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyteopenaire
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Clinics in Liver Disease, 2003
In summary, pegylated IFNs have a longer half-life, reduced immunogenicity, better pharmacokinetics, and enhanced biological activity when compared with standard IFN. Better adherence rates are feasible because of the once weekly administration of pegylated IFN. The adverse event profile is largely comparable. The improved pharmacokinetics of pegylated
Umaprasanna S, Karnam, K Rajender, Reddy
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In summary, pegylated IFNs have a longer half-life, reduced immunogenicity, better pharmacokinetics, and enhanced biological activity when compared with standard IFN. Better adherence rates are feasible because of the once weekly administration of pegylated IFN. The adverse event profile is largely comparable. The improved pharmacokinetics of pegylated
Umaprasanna S, Karnam, K Rajender, Reddy
openaire +4 more sources
Expert Opinion on Emerging Drugs, 2009
PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic ...
Jung Seok, Kang +2 more
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PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic ...
Jung Seok, Kang +2 more
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PEGylated Inorganic Nanoparticles
Angewandte Chemie International Edition, 2011AbstractApplication of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long‐term stability, and attachment of selective functional groups.
Karakoti, Ajay S. +3 more
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PEGylated Polyester-Based Nanoncologicals
Current Topics in Medicinal Chemistry, 2014Several PEGylated polyester-based nanoncologicals have been proposed in the literature, some of them nowadays being under preclinical/clinical trials or marketed. In this review, we describe the main features of PEGylated polyesters and their correspondent nanocarriers.
CONTE, CLAUDIA +4 more
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PEGylation of therapeutic proteins [PDF]
Biotechnology Journal, 2010 AbstractSince the first PEGylated product was approved by the Food and Drug Administration in 1990, PEGylation has been widely used as a post‐production modification methodology for improving biomedical efficacy and physicochemical properties of therapeutic proteins.
Roland E Kontermann
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Purification of PEGylated Proteins, with the Example of PEGylated Lysozyme and PEGylated scFv
2014PEGylation is a common and highly accepted possibility for half-life prolongation of proteins by increasing the hydrodynamic size. The chromatographic purification of PEGylated protein, using PEG (poly-ethylene glycol) of different PEG chain lengths, with the example of lysozyme and a scFv, is described in detail here, and helpful suggestions for the ...
Anna, Moosmann +2 more
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Process for protein PEGylation
Journal of Controlled Release, 2014PEGylation is a versatile drug delivery technique that presents a particularly wide range of conjugation chemistry and polymer structure. The conjugated protein can be tuned to specifically meet the needs of the desired application. In the area of drug delivery this typically means to increase the persistency in the human body without affecting the ...
Massimo Morbidelli
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