Results 211 to 220 of about 20,314 (255)

Effect of pegylation on pharmaceuticals

Nature Reviews Drug Discovery, 2003
Protein and peptide drugs hold great promise as therapeutic agents. However, many are degraded by proteolytic enzymes, can be rapidly cleared by the kidneys, generate neutralizing antibodies and have a short circulating half-life. Pegylation, the process by which polyethylene glycol chains are attached to protein and peptide drugs, can overcome these ...
J Milton Harris
exaly   +3 more sources

Pegylation

Clinical Pharmacokinetics, 2001
The use of liposomal carriers and the modification of therapeutic molecules through the attachment of poly(ethylene glycol) [PEG] moieties ('pegylation') are the most common approaches for enhancing the delivery of parenteral agents. Although 'classical' liposomes (i.e.
J M, Harris, N E, Martin, M, Modi
openaire   +2 more sources

Emerging PEGylated drugs

Expert Opinion on Emerging Drugs, 2009
PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic ...
Jung Seok, Kang, Patrick P, Deluca, Kang Choon, Lee   +2 more
openaire   +2 more sources

Synthesis of Pegylated Immunonanoparticles

Pharmaceutical Research, 2002
This work describes the synthesis of pegylated immunonanoparticles by conjugation of an anti-transferrin receptor monoclonal antibody (MAb) to maleimide-grafted pegylated nanoparticles prepared from poly(lactic acid) (PLA) and a bi-functional polyethyleneglycol (PEG).Maleimide-PEG3500-PLA40000 and methoxyPEG2600-PLA40000 copolymers were synthesized by ...
Jean-Christophe, Olivier, Ramon, Huertas, Hwa Jeong, Lee, Frederic, Calon, William M, Pardridge   +4 more
openaire   +2 more sources

PEGylated Inorganic Nanoparticles

Angewandte Chemie International Edition, 2011
AbstractApplication of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long‐term stability, and attachment of selective functional groups.
Karakoti, Ajay S., Das, Soumen, Thevuthasan, Suntharampillai, Seal, Sudipta   +3 more
openaire   +3 more sources

PEGylated Polyester-Based Nanoncologicals

Current Topics in Medicinal Chemistry, 2014
Several PEGylated polyester-based nanoncologicals have been proposed in the literature, some of them nowadays being under preclinical/clinical trials or marketed. In this review, we describe the main features of PEGylated polyesters and their correspondent nanocarriers.
CONTE, CLAUDIA, I. d'Angelo, MIRO, AGNESE, UNGARO, FRANCESCA, QUAGLIA, FABIANA   +4 more
openaire   +4 more sources

Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C

Journal of Controlled Release, 2001
Poly(ethyleneglycol) or PEG has proven to be of great value for a range of biomedical applications. A review the properties of PEG that lead to these applications is reported. Emphasis is placed on pharmaceutical uses of PEG--proteins, with specific discussion of the attributes of PEGylated alpha-interferon for treatment of hepatitis C.
A, Kozlowski, J M, Harris
openaire   +2 more sources

PEGYLATION: an important approach for novel drug delivery system

Journal of Biomaterials Science, Polymer Edition, 2021
Hitesh Kumar Dewangan
exaly  

To PEGylate or not to PEGylate, that is not the question

Journal of Controlled Release, 2010
openaire   +2 more sources

Peptide and protein PEGylation

Biomaterials, 2001
Francesco M Veronese, F M Veronese
exaly