Results 211 to 220 of about 32,225 (250)
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Biomacromolecules, 2010
Thermoresponsive oligo(ethylene glycol)-based copolymers were investigated for trypsin conjugation. These copolymers have been synthesized by atom transfer radical polymerization of 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) with oligo(ethylene glycol) methyl ether methacrylate (OEGMA(475), M(n) = 475 g.mol(-1)) at 60 degrees C in the presence of
Zarafshani, Z., Obata, T., Lutz, J.
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Thermoresponsive oligo(ethylene glycol)-based copolymers were investigated for trypsin conjugation. These copolymers have been synthesized by atom transfer radical polymerization of 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) with oligo(ethylene glycol) methyl ether methacrylate (OEGMA(475), M(n) = 475 g.mol(-1)) at 60 degrees C in the presence of
Zarafshani, Z., Obata, T., Lutz, J.
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Synthesis of Pegylated Immunonanoparticles
Pharmaceutical Research, 2002This work describes the synthesis of pegylated immunonanoparticles by conjugation of an anti-transferrin receptor monoclonal antibody (MAb) to maleimide-grafted pegylated nanoparticles prepared from poly(lactic acid) (PLA) and a bi-functional polyethyleneglycol (PEG).Maleimide-PEG3500-PLA40000 and methoxyPEG2600-PLA40000 copolymers were synthesized by ...
Jean-Christophe, Olivier +4 more
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Clinical Pharmacokinetics, 2001
The use of liposomal carriers and the modification of therapeutic molecules through the attachment of poly(ethylene glycol) [PEG] moieties ('pegylation') are the most common approaches for enhancing the delivery of parenteral agents. Although 'classical' liposomes (i.e.
J M, Harris, N E, Martin, M, Modi
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The use of liposomal carriers and the modification of therapeutic molecules through the attachment of poly(ethylene glycol) [PEG] moieties ('pegylation') are the most common approaches for enhancing the delivery of parenteral agents. Although 'classical' liposomes (i.e.
J M, Harris, N E, Martin, M, Modi
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Ligand-installed PEGylated bionanosphere
IEE Proceedings - Nanobiotechnology, 2005The synthesis of poly(ethylene glycol)-b-poly(2-N,N-dimethylaminoethylmethacrylate) processing an acetal group at the PEG chain end (acetal-PEGPAMA) is reported. The obtained acetal-PEGPAMA block copolymer was found to reduce tetrachloroauric acid at room temperature to produce gold nanoparticles. The size of these nanoparticles was controllable in the
Y, Nagasaki, K, Kataoka
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International Journal of Peptide and Protein Research, 1995
Conditions have been developed for the site‐specific pegylation (NH2‐terminus, side‐chain and carboxyterminus) of a potent analog of growth hormone‐releasing factor, [Ala15]‐hGRF(1‐29)‐NH2. These pegylated peptides were prepared by solid‐phase peptide synthesis using the Fmoc/tBu strategy, and were fully characterized by analytical HPI.C, amino‐acid ...
A M, Felix, Y A, Lu, R M, Campbell
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Conditions have been developed for the site‐specific pegylation (NH2‐terminus, side‐chain and carboxyterminus) of a potent analog of growth hormone‐releasing factor, [Ala15]‐hGRF(1‐29)‐NH2. These pegylated peptides were prepared by solid‐phase peptide synthesis using the Fmoc/tBu strategy, and were fully characterized by analytical HPI.C, amino‐acid ...
A M, Felix, Y A, Lu, R M, Campbell
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Reviews in gastroenterological disorders, 2002
Interferon therapy for chronic hepatitis C is not a cure, but it is able to decrease the viral load and may decrease the risk of complications (e.g., cirrhosis, liver failure, liver cancer). Pegylation of the interferon increases the amount of time the interferon remains in the body by increasing the size of the interferon molecule. Increasing molecule
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Interferon therapy for chronic hepatitis C is not a cure, but it is able to decrease the viral load and may decrease the risk of complications (e.g., cirrhosis, liver failure, liver cancer). Pegylation of the interferon increases the amount of time the interferon remains in the body by increasing the size of the interferon molecule. Increasing molecule
openaire +1 more source