Results 41 to 50 of about 438,568 (317)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Taste-Masked Pellets of Warfarin Sodium: Formulation towards the Dose Personalisation

Pharmaceutics
The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to ...
Lakija Kovalenko, Kirils Kukuls, Marta Berga, Valentyn Mohylyuk   +3 more
doaj   +1 more source

Evaluation of Agricultural Residues as Organic Green Energy Source Based on Seabuckthorn, Blackberry, and Straw Blends

Agronomy, 2022
The use of biomass mixtures as a feedstock in the production of pellets requires optimization of the percentages of the components, since interactions occur during combustion between the components forming the blend (lignin, cellulose, and hemicellulose),
Grigore Marian, Gelu Ianuș, Bogdan Istrate, Alexandru Banari, Boris Nazar, Corneliu Munteanu, Teodor Măluțan, Andrei Gudîma, Florin Ciolacu, Nicolae Daraduda, Viorel Paleu   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Morphological and ecological screening of different collections of medicinal white-rot bracket fungus Ganoderma adspersum (Schulzer) Donk (Agaricomycetes, Polyporales)

Italian Journal of Mycology, 2019
The screening of morphological and growth characteristics of mycelial collections of medicinal bracket fungus Ganoderma adspersum (Agaricomycetes, Polyporales) of different geographical origins (Armenia, Georgia, Iran) on malt-extract agar (MEA) and ...
Susanna M. Badalyan, Narine G. Gharibyan, Mirco Iotti, Alessandra Zambonelli   +3 more
doaj   +1 more source

Design of Oral Sustained-Release Pellets by Modeling and Simulation Approach to Improve Compliance for Repurposing Sobrerol

Pharmaceutics, 2022
Sobrerol, an oral mucolytic agent, in a recent study showed promise for treating multiple sclerosis. A human equivalent dose of 486 mg of sobrerol administered thrice daily (i.e., 1459 mg of daily dose) demonstrated the highest therapeutic efficacy for ...
Chu-Hsun Lu, Yu-Feng Huang, I-Ming Chu
doaj   +1 more source

Design, Manufacture, and Performance Testing of Extrusion–Pultrusion Machine for Fiber-Reinforced Thermoplastic Pellet Production [PDF]

, 2021
Cahyo Budiyantoro, Heru Santoso Budi Rochardjo, Gesang Nugroho   +2 more
openalex   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Substantiation of manufacture technology development for the tablets of isosorbide dinitrate with modified release

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Isosorbide dinitrate belongs to the group of organic nitrates, the oldest representatives of antianginal drugs, and today is the first-choice drug for purchase and prevention of strokes. High prophylactic efficacy of prolonged forms of nitrates should be
D. S. Oliinykov, A. H. Kaplaushenko
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source