Results 71 to 80 of about 40,026 (289)

Enhancing the potency of 5T4 mRNA vaccine by CD70 mRNA-LNPs through ADCC and T cell boosting in prostate cancer therapy

Journal of Nanobiotechnology
Background Prostate cancer remains a significant health challenge, as conventional treatments often fail to provide long-term benefits in the advanced stages.
Fei Cao, Yuandong Xu, Yupeng Guan, Kexin Zhang, Haowei Qiu, Zhen Xu, Yunru He, Ze Xiu Xiao, Gao-feng Zha, Jun Pang   +9 more
doaj   +1 more source

Symptomatic pelvic floor disorders and its associated factors in South-Central Ethiopia.

PLoS ONE, 2021
IntroductionPelvic floor disorders (PFD) are gynecologic health problems containing a wide variety of clinical problems; the most prevalent problems are pelvic organ prolapse, fecal incontinence, and urinary incontinence.
Eskedar Demissie Beketie, Wubishet Tesfaye Tafese, Zebene Mekonnen Assefa, Fantahun Walle Berriea, Genet Asfaw Tilahun, Bisrat Zeleke Shiferaw, Natnael Eshetu Teke   +6 more
doaj   +1 more source

Significant kidney impairment in pediatric inflammatory bowel disease and practice points for pediatric gastroenterologists

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Children with inflammatory bowel disease (IBD) have an increased risk of developing kidney disorders, which may cause significant kidney function impairment (SKI) or lead to chronic kidney disease (CKD). In this study we aimed to provide insights in causes and diagnoses of SKI cases and to provide recommendations for pediatric ...
Stephanie A. Vuijk, Renz C. W. Klomberg, Tobias Schwerd, Anne M. Griffiths, Séamus Hussey, Matthew W. Carroll, Petter Malmborg, Protima Deb, Margreet Wessels, Natalia Mouratidou, Stephanie van Biervliet, Michael Friedt, Susie Minson, Femke H. M. Vrieling‐Prince, Nicholas M. Croft, Lissy de Ridder, the PIBD‐SETQuality Safety Registry collaborative group   +16 more
wiley   +1 more source

Association of cigarette use with risk of prostate cancer among US males: a cross-sectional study from NHANES 1999–2020

BMC Public Health
Background Association of cigarette use with risk of prostate cancer remains unclear. We performed this study to examine whether cigarette use is associated with increased risk of prostate cancer.
Xiangwei Yang, Hong Chen, Junfu Zhang, Shiqiang Zhang, Yongda Socrates Wu, Jun Pang   +5 more
doaj   +1 more source

Recognizing myofascial pelvic pain in the female patient with chronic pelvic pain. [PDF]

, 2012
Myofascial pelvic pain (MFPP) is a major component of chronic pelvic pain (CPP) and often is not properly identified by health care providers. The hallmark diagnostic indicator of MFPP is myofascial trigger points in the pelvic floor musculature that ...
Katzman, Wendy B, Pastore, Elizabeth A
core   +1 more source

Circadian patterns in postvoid residual and voided percentage among older women with urinary incontinence [PDF]

, 2020
Background: Women with urinary incontinence incur an increased risk of elevated postvoid residual (PVR) volume and impaired voiding efficiency (i.e., voided percentage (Void%)), but the clinical significance of these parameters remains poorly described ...
Decalf, Veerle, Denys, Marie-Astrid, Everaert, Karel, Monaghan, Thomas, Petrovic, Mirko, Pieters, Ronny, Weiss, Jeffrey   +6 more
core   +2 more sources

A post hoc analysis of linaclotide in pediatric patients with functional constipation and neurodevelopmental disorders

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Functional constipation (FC) is common in children with comorbid neurodevelopmental disorders (NDD) and its optimal treatment may be challenged by adherence and medication tolerability issues in this population. We assessed the efficacy and safety of linaclotide in pediatric patients with FC and NDD.
Hannibal Person, Jeffrey S. Hyams, Rinarani M. Sanghavi, Valentina Shakhnovich, Katherine Kosch, Moming Li, Danielle D'Achino, Julie Khlevner, Bruno P. Chumpitazi, Miguel Saps   +9 more
wiley   +1 more source

A Novel Semi‐Quantified Method for Grading Sonographic Severity of Adenomyosis and its Relation With Clinical Symptoms

Journal of Ultrasound in Medicine, EarlyView.
Objective To correlate the sonographic severity of adenomyosis, assessed with real‐time ultrasound and a novel semi‐quantified method (XI‐VOCAL counting and categories) with adenomyosis‐associated symptoms. Methods This observational study was conducted in a tertiary referral outpatient clinic.
Lisa M. Trommelen, Cilla Verbeek, Thierry van den Bosch, Karin P. M. van Galen, Judith A. F. Huirne, Robert A. de Leeuw   +5 more
wiley   +1 more source

Fractional CO2 Laser Treatment for Female Vaginal Relaxation Syndrome: A Prospective Study

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Background Vaginal relaxation syndrome (VRS) is a common condition that adversely affects women's quality of life. Conventional non‐surgical therapies provide limited benefit for patients with mild to moderate disease. Fractional CO2 laser (FxCO2) therapy has emerged as a minimally invasive treatment option; however, its long‐term efficacy and
Qiao Li, Jian Meng, Yajing Wang, Yueyue Chen, Xiaoyu Niu, Dongmei Wei   +5 more
wiley   +1 more source

Clinical Outcome Assessments for Functional Performance in Spastic Paresis: Systematic Review, Critique, and Recommendations

Movement Disorders, EarlyView.
Abstract Background Spastic paresis, resulting from central nervous system lesions, significantly impairs functional performance. In the framework of the International Classification of Functioning, Disability, and Health, functional performance was defined as functioning at the activity level in relation to the impairment of body functions and ...
Martina Hoskovcova, Marjolaine Baude, Bo Biering‐Sørensen, Ota Gal, Mary P Galea, Jean‐Michel Gracies, Carmen Rodriguez‐Blazquez, Theodore Wein, Michelle Hyczy de Siqueira Tosin, Álvaro Sánchez‐Ferro, Tiago A Mestre, Matej Skorvanek, Robert Jech, The members of the MDS Clinical Outcome Assessments Scientific Evaluation Committee and MDS Spasticity Study Group   +13 more
wiley   +1 more source