Results 91 to 100 of about 432,483 (351)

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

A pelvic pleomorphic hyalinizing angiectatic tumor: a rare case report

PAMJ Clinical Medicine, 2019
Pleomorphic hyalinizing angiectatic tumor (PHAT) is a particular rare entity corresponding to soft tissue neoplasm with low malignant potential. The exact etiopathology responsible for the tumor occurrence is not exactly identified.
Meriem Braiki, Mohamed Azzaza, Moncef Mokni, Khaled Sakly, Dorra Daly, Fethi Derbe   +5 more
doaj   +1 more source

Laparoscopic resection of metastatic pelvic liposarcoma

International Brazilian Journal of Urology, 2006
We report a pelvic liposarcoma originating from the left spermatic cord that recurred following inadequate excision. In our case, the tumor was resected without performing orchiectomy previously.
Hong B. Shim, Tae Y. Jung, Ja H. Ku
doaj   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Evaluation of Efficacy and Safety of 2 mg vs 4 mg Dienogest in Endometriosis: A Randomised Single-blind Dose-ranging Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Endometriosis is a recurring chronic inflammatory condition that affects females of reproductive age. Endometriosis-associated Pelvic Pain (EAPP) adversely impacts physical, mental, and social well-being.
Suparna Biswas, Raghunath Bhattacharyya, Sumit Ranjan Pramanik, Neha Jain, Subhash Chandra Biswas   +4 more
doaj   +1 more source

NASA/FAA general aviation crash dynamics program [PDF]

, 1981
The program involves controlled full scale crash testing, nonlinear structural analyses to predict large deflection elastoplastic response, and load attenuating concepts for use in improved seat and subfloor structure.
Carden, H. D., Hayduk, R. J., Thomson, R. G.   +2 more
core   +1 more source

Orthopedic Surgery Planning Based on the Integration of Reverse Engineering and Rapid Prototyping [PDF]

, 2004
This paper describes orthopedic surgical planning based on the integration of RE and RP. Using symmetrical characteristics of the human body, CAD data of the original bone without damages for the injured extent are generated from a mirror ...
Ahn, Dong-Gyu, Lee, Jun-Young, Yang, Dong-Yol   +2 more
core   +1 more source

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

Advanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao, Huaxian Chen, Jiao Li, Yihui Zheng, Liqing Xie, Guozhong Xiao, Zeyan Wang, Fen Yuan, Junhong Chen, Chongbao Sun, Jing Dai, Jinping Zeng, Xinhua Wang, Lei Wu, Hongcheng Lin   +14 more
wiley   +1 more source

Delayed internal fixation on unstable bone pelvic fracture

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2023
The frequency of pelvic fractures is low, but the associated mortality is extremely high. Its treatment represents a great challenge for health professionals, both clinically and surgically.
Yulay Enrique Hernández-Rojas, Héctor Gabriel Díaz-Carrillo   +1 more
doaj