Results 111 to 120 of about 207,565 (299)

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Impact of Environmental Weathering on the Chemical Composition of Spilled Oils in a Real Case in Brazil

Coasts
Brazil suffered the largest oil spill disaster in its history, beginning on August 2019, affecting the Northeast coast. This study proposes a chemical investigation of oils from the 2019 spill in Brazil, which had naturally undergone different weathering
Ana Beatriz A. de M. Salata, Marília G. A. Pereira, Isabelle F. S. de Lima, Ignes Regina dos Santos, Danielle M. M. Franco, Boniek G. Vaz, Jandyson M. Santos   +6 more
doaj   +1 more source

AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression

Molecular Oncology, 2019
Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first‐line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and pyrimidine synthesis, and elevated activity of these enzymes in tumors
Yiyang Qin, Ikuo Sekine, Michiko Hanazono, Takao Morinaga, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Naoto Yamaguchi, Masatoshi Tagawa   +9 more
doaj   +1 more source

A globally convergent matricial algorithm for multivariate spectral estimation

, 2008
In this paper, we first describe a matricial Newton-type algorithm designed to solve the multivariable spectrum approximation problem. We then prove its global convergence.
Ferrante, Augusto, Pavon, Michele, Ramponi, Federico   +2 more
core   +1 more source

Engineering and Characterization of a Fluorescent Fission Yeast Arp2/3 Complex for Single Molecule Mechanistic Investigations

Cytoskeleton, EarlyView.
ABSTRACT Arp2/3 complex is a seven‐component protein complex that facilitates the assembly of branched actin filament networks by binding to pre‐existing “mother” actin filaments and initiating the nucleation of new branched “daughter” filaments. Arp2/3 complex must be activated by a nucleation promoting factor such as the WASP/Scar protein family. The
Caitlin A. Anderson, Meghan E. O'Connell, Kaitlin E. Homa, Cristian Suarez, Michael L. James, Kashmeera D. Baboolall, Vilmos Zsolnay, Vladimir Sirotkin, David R. Kovar   +8 more
wiley   +1 more source

A multi-objective optimisation model for a general polymer electrolyte membrane fuel cell system [PDF]

, 2010
This paper presents an optimisation model for a general polymer electrolyte membrane (PEM) fuel cell system Suitable for efficiency and size trade-offs investigation.
Ang, SMC, Brett, DJL, Fraga, ES
core  

Hierarchical models for semi-competing risks data with application to quality of end-of-life care for pancreatic cancer

, 2015
Readmission following discharge from an initial hospitalization is a key marker of quality of health care in the United States. For the most part, readmission has been used to study quality of care for patients with acute health conditions, such as ...
Dominici, Francesca, Haneuse, Sebastien, Lee, Kyu Ha, Schrag, Deborah   +3 more
core   +2 more sources

Going from Pt to PGM‐free Catalysts: Effects of Ink Compositions on PEM Water Electrolysis

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Optimisation of cathode ink formulations regarding the ratio between catalyst, carbon and binder results in a boost in PEM water electrolysis performance. The optimisation can be transferred from pentlandites to platinum and selenide catalysts, wherein the metal chalcogenides show a stronger performance enhancement.
Janna Wierper, Jannick Hiltrop, Kevinjeorjios Pellumbi, Julia Jökel, Sebastian Sanden, Miłosz Kożusznik, Andrzej Mikuła, Ulf‐Peter Apfel   +7 more
wiley   +1 more source

Sustainable Hydrogen Production by Glycerol and Monosaccharides Catalytic Acceptorless Dehydrogenation (AD) in Homogeneous Phase

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Sustainable hydrogen production can be obtained from hydogen‐rich biomass‐derived organic molecules through Acceptorless Dehydrogenation (AD) reactions. Glycerol and sugars are available in large quantities from industry and can be successfully used as substrates in AD protocols, in the presence of tailored, selective, easily tunable and thermally ...
Sylwia Kostera, Luca Gonsalvi
wiley   +1 more source

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer

CPT: Pharmacometrics & Systems Pharmacology, 2019
Bevacizumab‐pemetrexed/cisplatin (BEV‐PEM/CIS) is a first‐line therapeutic for advanced nonsquamous non‐small cell lung cancer. Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization.
Benjamin K. Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlesi, Kenneth Wang, Sebastien Benzekry, Jonathan P. Mochel   +6 more
doaj   +1 more source