Results 61 to 70 of about 25,191 (237)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Pemphigus: use of the Japanese severity index in 56 Moroccan patients

The Pan African Medical Journal, 2013
INTRODUCTION: In pemphigus, there still is no consensus on parameters mesuring clinically the disease severity. The aim of this study is to use the Japanese severity index in Moroccan patients with pemphigus.
Hakima Benchikhi, Samira Nani, Hanane Baybay, Said Amal, Fatim-Zahra Mernissi   +4 more
doaj   +1 more source

Incidência do pênfigo vulgar ultrapassa a do pênfigo foliáceo em região endêmica para pênfigo foliáceo: análise de série histórica de 21 anos Incidence of pemphigus vulgaris exceeds that of pemphigus foliaceus in a region where pemphigus foliaceus is endemic: analysis of a 21-year historical series

Anais Brasileiros de Dermatologia, 2011
FUNDAMENTO: Há dois tipos principais de pênfigo: pênfigo vulgar e pênfigo foliáceo. Nos últimos anos, mudanças clínicas e epidemiológicas relacionadas aos pênfigos têm sido observadas.
Gilson Antonio Pereira Gonçalves, Moema Mignac Cumming Brito, Adriana Martinelli Salathiel, Thais Serraino Ferraz, Domingos Alves, Ana Maria Ferreira Roselino   +5 more
doaj   +1 more source

Ocular and cutaneous infection due to Curvularia pseudobrachyspora in an immunosuppressed dog: Case report and in vitro antimycotic susceptibilities

Australian Veterinary Journal, EarlyView.
A 3‐year‐old male Border Collie diagnosed with immune‐mediated dermatopathy, managed with tapering prednisolone and cyclosporine, developed rapidly progressive ocular signs and additional cutaneous lesions. Histopathology, mycological culture, polymerase chain reaction and sequencing confirmed intraocular and cutaneous infection due to Curvularia ...
T Brasil‐Ervedosa, R Clark, J Granados‐Soler, C Palmieri, V Gonzalez‐Astudillo   +4 more
wiley   +1 more source

Pemphigus foliaceus transforming to pemphigus vulgaris: a case report

Frontiers in Medicine
Pemphigus represents a family of acantholytic autoimmune vesiculobullous diseases. It is classified into multiple subtypes, the two most common of which are pemphigus vulgaris and pemphigus foliaceus. The transition between these two subtypes is uncommon.
Mandlin Abdulaziz Almousa, Mandlin Abdulaziz Almousa, Mandlin Abdulaziz Almousa, Mandlin Abdulaziz Almousa, Navya Kuchibhotla, Navya Kuchibhotla, Navya Kuchibhotla, Lama Alabdulaaly, Lama Alabdulaaly, Lama Alabdulaaly, Lama Alabdulaaly, Marcus Couey, Vikki Noonan, Herve Sroussi, Herve Sroussi, Herve Sroussi   +15 more
doaj   +1 more source

Pemphigus scoring systems and their validation studies – A review of the literature

Dermatologica Sinica, 2023
Pemphigus is a rare autoimmune blistering disease that affects the skin and mucous membranes. Despite recent advances in treatment, pemphigus is associated with high patient mortality and has a significantly negative impact on patients' quality of life ...
Darby Boucher, Anna Wilson, Dedee F Murrell   +2 more
doaj   +1 more source

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Frontiers in Immunology, 2019
Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1).
Roberta Lotti, Claudio Giacinto Atene, Alessandra Marconi, Giulia Di Rocco, L. Reggiani Bonetti, Tommaso Zanocco Marani, Carlo Pincelli   +6 more
doaj   +1 more source

Utility of IgG4 immunohistochemistry detection in pemphigus diagnosis

SAGE Open Medical Case Reports, 2022
Pemphigus includes a group of blistering autoimmune diseases that affect the skin and mucosa, characterized by the formation of epidermal bullous and the presence of antibodies against binding proteins.
Maricela García-Lechuga, María Elisa Vega-Memije, Ana Isabel Montiel-Rangel, Andres Torres-González, Lucia Rangel-Gamboa   +4 more
doaj   +1 more source

Diagnostic difficulties in a case of a female patient with pemphigus vulgaris

, 2016
Introduction . Autoimmune blistering diseases are mediated by autoantibodies directed against structural proteins of the skin. Pemphigus vulgaris (PV) is the most common type of pemphigus.
Kamila Zawadzińska-Halat, Jerzy Jarząb, Agata Filipowska-Grońska, Karolina Filipowska, Maria Weryńska-Kalemba   +4 more
core   +1 more source