Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
About Contractual Risks and Private Law Means of Mitigating Them
The risks of contracts are increasing nowadays. The reasons for this are increasing economic and social uncertainties. The role of important contract law principles, such as vis maior, pacta sunt servanda, or clausula rebus sic stantibus, has changed ...
Tibor Nochta
doaj +1 more source
The effect of the penalty system on market prices in the Korea ETS
This study analyzes the effect of the penalty system in an emission trading scheme (ETS) on pricing and abatement activities. No previous studies have shown that the ways of penalizing for unretired permits specifically might have a crucial role in ...
Weonseek Kim, Jongmin Yu
doaj +1 more source
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
Lapse of rights connected with assignment of legal claims, problematic issues and their solution
Impact of transfer of legal claim on the destiny of rights security and connected claims may differ. The aim of the article is to analyze the transfer of rights connected with transferred legal claims, to survey the problematic issues and to suggest ...
Nemenova V.
doaj +1 more source
Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley +1 more source
A Topology Optimization Framework for the Inverse Design of Nonlinear Mechanical Metamaterials
This work uses topology optimization to design unit cells for mechanical metamaterials with a prescribed nonlinear stress–strain response. The framework adds contact and postbuckling modeling to synthesize microstructures for three highly nonlinear responses, including pseudoductile behavior, monostable with snap‐through buckling, and bistable ...
Charlie Aveline +2 more
wiley +1 more source
Liability of construction participants for delays
Date of completion is usually set forth in construction contract agreements as one of the most important provisions. Also, it is the provision, which is often violated and the violation results in a dispute between the parties to the agreement.
Sigitas Mitkus, Aurelija Sekonaitė
doaj +1 more source
Unleashing the Power of Machine Learning in Nanomedicine Formulation Development
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore +7 more
wiley +1 more source
Block Copolymers: Emerging Building Blocks for Additive Manufacturing
This review addresses how block copolymer (BCP) physics and rheology have led to the widespread use of BCPs in advanced additive manufacturing techniques, with particular emphasis on the untapped potential of these nanostructured materials toward achieving multi‐scale architected materials with unique, programmable material properties.
Alice S. Fergerson +3 more
wiley +1 more source

