Results 31 to 40 of about 202,371 (297)

Fatores prognósticos nos ferimentos cervicais penetrantes Prognostic factors of penetrating neck trauma

Brazilian Journal of Otorhinolaryngology, 2011
O pescoço é vulnerável a traumatismos devido à grande quantidade de estruturas vitais, podendo ocorrer lesões importantes e com alta morbimortalidade. OBJETIVO: Avaliar resultados em pacientes vítimas de ferimentos penetrantes cervicais.
José Cruvinel Neto, Rogério Aparecido Dedivitis   +1 more
doaj   +1 more source

Clinical Characteristics, Histopathology, and Treatment Outcomes of Pythium Keratitis: A Retrospective Cohort Study

Clinical Ophthalmology, 2021
Vilavun Puangsricharern,1,2 Patraramon Chotikkakamthorn,2 Wasee Tulvatana,1 Thanachaporn Kittipibul,2 Patchima Chantaren,2 Usanee Reinprayoon,2 Ngamjit Kasetsuwan,1,2 Vannarut Satitpitakul,2 Navaporn Worasilchai,3,4 Ariya Chindamporn3 1Department of ...
Puangsricharern V, Chotikkakamthorn P, Tulvatana W, Kittipibul T, Chantaren P, Reinprayoon U, Kasetsuwan N, Satitpitakul V, Worasilchai N, Chindamporn A   +9 more
doaj  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Patterns of ocular trauma among the elderly in a South-American urban area and the association between eye traumas with sleep disorders

Journal of Emergencies, Trauma and Shock, 2017
Aims: Eye trauma in the older population can lead to blindness. Sleep deterioration is associated with increased risk of occupational injuries. The purpose of the study was to assess the epidemiology of ocular trauma in the elderly population and to ...
Sergio Henrique N Moreira, Niro Kasahara
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

An unusual impalement injury to knee

Journal of Dr. NTR University of Health Sciences, 2020
Impalement injuries are one of the severe types of injuries combining effects of both penetrating and blunt trauma leading to crushing injury, wound contamination, and multi-organ damage.
Hitesh A R. Kodidasu, Arun K Murugan, Chandra Sekhar Siddanathi, Ashok K Patnala   +3 more
doaj   +1 more source

Oncological outcomes of Crohn's disease‐associated cancers focusing on disease behavior

Annals of Gastroenterological Surgery, 2023
Background The overall risk of colorectal cancer in Crohn's disease (CD) is higher than in the general population, and CD‐associated cancer (CDAC) has poorer prognosis than sporadic cancer.
Akira Yamamoto, Yuji Toiyama, Hiroki Ikeuchi, Motoi Uchino, Kitaro Futami, Kinya Okamoto, Takayuki Ogino, Soichiro Ishihara, Yoichi Ajioka, Kenichi Sugihara, for the Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum   +10 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source