Results 51 to 60 of about 278,592 (291)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Cell-Penetrating Peptides

, 2021
In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short overview of CPP history and discuss several aspects of CPP classification. Next section is devoted to the mechanism of CPP penetration into the cells, where direct
Ülo Langel, Zorko, Matjaž, Langel, Ülo,, Matjaž Zorko   +3 more
core   +1 more source

Patterns of ocular trauma among the elderly in a South-American urban area and the association between eye traumas with sleep disorders

Journal of Emergencies, Trauma and Shock, 2017
Aims: Eye trauma in the older population can lead to blindness. Sleep deterioration is associated with increased risk of occupational injuries. The purpose of the study was to assess the epidemiology of ocular trauma in the elderly population and to ...
Sergio Henrique N Moreira, Niro Kasahara
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Fever of Unknown Origin and Penetrating Aortic Ulcer Successfully Treated with Thoracic Endovascular Aortic Repair—A Case Report

Diagnostics
Background and Clinical Significance: Fever of undetermined origin (FUO is a diagnostic challenge. It is essential to exclude infections, paraneoplastic syndromes, and large-vessel vasculitis (LVV).
Tomislav Jakljević, Franka Kunovac, Tatjana Zekić, Vjekoslav Tomulić   +3 more
doaj   +1 more source

Delayed diagnosis of traumatic ventricular septal perforation in penetrating chest injury: hematoma formation in the ventricular septum in CT suggests perforation

Acute Medicine & Surgery, 2019
Background Ventricular septal perforation (VSP) can be caused by a penetrating cardiac injury. Diagnosis of VSP tends to be delayed because a shunt might not be detected by color flow Doppler at an early stage following injury.
Nobuki Shioya, Nozomu Inoue, Harutatsu Muto, Akiko Tomita, Yuki Tsukamoto, Naonori Kawashima, Koji Hazama, Yasuo Shichinohe   +7 more
doaj   +1 more source

Fatores prognósticos nos ferimentos cervicais penetrantes Prognostic factors of penetrating neck trauma

Brazilian Journal of Otorhinolaryngology, 2011
O pescoço é vulnerável a traumatismos devido à grande quantidade de estruturas vitais, podendo ocorrer lesões importantes e com alta morbimortalidade. OBJETIVO: Avaliar resultados em pacientes vítimas de ferimentos penetrantes cervicais.
José Cruvinel Neto, Rogério Aparecido Dedivitis   +1 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Preoperative evaluation of penetrating esophageal trauma in the current era: An analysis of the National Trauma Data Bank

Journal of Emergencies, Trauma and Shock, 2015
Background: Preoperative diagnostic evaluation (PDE) of penetrating esophageal injury (PeEsIn) can delay treatment and increase morbidity. We sought to study the relationship among PDE, delay in definitive treatment, and patient mortality in PeEsIn ...
Daniel Dante Yeh, John O Hwabejire, Marc de Moya, David R King, Peter Fagenholz, Haytham MA Kaafarani, Eric N Klein   +6 more
doaj   +1 more source

Laparoscopic Management of Stab Wound of Anterior Abdominal Wall: A Prospective Stud [PDF]

Ain-Shams Journal of Surgery, 2016
Background: The anterior abdominal wall is one of the most common regions affected in penetrating stab wound injuries. Tradionally, wound exploration and exploratory laparotomy are used as a diagnostic and therapeutic modality in the management of such ...
Moheb Shoraby, Ashraf Hegab, Ahmed A Darwish   +2 more
doaj   +1 more source