Results 171 to 180 of about 802,819 (312)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Penetration testing automation assessment method based on rule tree

, 2015
With the application to assess the network and system security in some key fields, penetration testing assessment methods have been evolving into a popular research topic.
Shang WL(尚文利), Wan M(万明), Zeng P(曾鹏), Zhao JM(赵剑明)   +3 more
core  

Comparative Evaluation of Depth of Irrigant Penetration Using Different Irrigation Systems: An In Vivo Study. [PDF]

Cureus
Ohm A, Manan R, Mishra P, Chauhan B, Gutti AB, Soni A.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique

, 2016
Charu Sharma,1,2 Nihar R Biswas,1 Shreesh Ojha,3 Thirumurthy Velpandian1 1Department of Ocular Pharmacology and Pharmacy, All India Institute of Medical Sciences, New Delhi, India; 2Department of Internal Medicine, 3Department of Pharmacology and ...
Ojha S, Sharma C, Velpandian T, Biswas NR   +3 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Pharmacokinetics and skin-tissue penetration of daptomycin in rats

, 2015
Kazuaki Matsumoto,1 Masashi Kitaoka,1 Yuko Kuroda,1 Kazuro Ikawa,2 Norifumi Morikawa,2 Junichi Sasaki,3 Osamu Iketani,4 Satoshi Iwata,4 Tetsuya Horino,5 Seiji Hori,5 Junko Kizu1 1Division of Practical Pharmacy, Keio University Faculty of Pharmacy, Tokyo,
Sasaki J, Iwata S, Matsumoto K, Kitaoka M, Kuroda Y, Iketani O, Morikawa N, Ikawa K, Horino T, Hori S, Kizu J   +10 more
core  

Investigation on Cutting Fluid Penetration Kinetics and Friction Reduction Mechanism of Micro-Textured Tools via Direct Vapor-Phase Capillary Filling. [PDF]

Materials (Basel)
Ge D, Ma J, Liu A, Tang Z, Wu J, Sun Y, Zhang Y.   +6 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Mechanical Properties and Fabrication of Bioinspired Cactus Spine Microneedles. [PDF]

Biosensors (Basel)
Liu H, Long X, Sun Q, Wu S, Yuan Z.
europepmc   +1 more source