Results 51 to 60 of about 2,342,703 (300)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Relationship between DIAGNOdent values and sealant penetration depth on occlusal fissures [PDF]
, 2010 The aim of this in vitro study was to evaluate the relationship between laser fluorescence values and sealant penetration depth on occlusal fissures. One hundred and sixty-six permanent molars were selected and divided into four groups, which were each ...
Diniz, Michele B +9 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discussion of penetration depth of ship anchoring based on finite element method
Shuili Shuiyun Gongcheng Xuebao, 2022 The accurate calculation of the penetration depth of ship anchoring is of vital importance to the safety of pipeline projects passing through anchorage areas and navigation channels below the riverbed.
YU Bowen, CHEN Li, LIU Rui
doaj +1 more source
Penetration of fastener projectiles into construction materials [PDF]
, 1988 The normal impact, penetration of both projectile and fastener into soils, rocks, and concrete at low velocities has been investigated using theoretical, experimental, and numerical approaches under axisymmetric conditions.
Zhou, Gang
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Photodiagnosis and Photodynamic TherapyObjectives: This study compared the effects of conventional, ultrasonic, and laser-activated irrigation (LAI) on penetration depth of three photosensitizers (PSs) in the root canal system.
Siavash Jafari Semnani +3 more
doaj +1 more source
A Predictive Depth of Penetration Model for Abrasive Waterjet Cutting of Polymer Matrix Composites [PDF]
, 2002 A common defective phenomenon in abrasive waterjet (AWJ) cutting of layered materials such as polymer matrix composites is delamination which occurs only when the jet is unable to cut through the workpiece.
Guo, Dongming, Wang, Jun, Guo, D.M.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Soil conditions and bounds to suction during the installation of caisson foundations in sand [PDF]
, 2014 Suction installation of caisson foundations is widely adopted in the oil offshore industry. When such foundations are installed in sand, seepage conditions are known to play a pivotal role in the installation process.
Alani, Amir M. +4 more
core +1 more source