Results 61 to 70 of about 2,342,703 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Topical Application of Glycerol Increases Penetration Depth of Optical Coherence Tomography in Diagnosis of Basal Cell Carcinoma

Acta Dermato-Venereologica, 2021
Optical coherence tomography is a non-invasive imaging technique that enables high-resolution in vivo imaging of skin. Although optical coherence tomography is promising for diagnosing basal cell carcinoma, its limited penetration depth may impede basal ...
Fieke Adan, Ellen M.M. Oyen, Robert J. Holtackers, Eva van Loo, Gert-Jan Dermont, Nicole W.J. Kelleners-Smeets, Patty J. Nelemans, Klara Mosterd   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Role of welding parameters on interfacial bonding in dissimilar steel/aluminum friction stir welds

Engineering Science and Technology, an International Journal, 2015
In this study, lap welds between Al5754 to DP600 steel (aluminum plate top, and steel plate bottom) were manufactured by friction stir welding (FSW). The effects of welding parameters (i.e.
Z. Shen, Y. Chen, M. Haghshenas, A.P. Gerlich   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The depth of sorbath penetration in periodic adsorption processes

Holodilʹnaâ Tehnika i Tehnologiâ, 2018
The depth of sorbate penetration into the adsorbent grains is a new dimensional criterion for estimating efficiency of using the adsorbent in periodic adsorption and desorption processes.
M.B. Kravchenko
doaj   +1 more source

Estimation of Penetration Depth Using Acceleration Signal Analysis for Underwater Free Fall Cone Penetration Tester

한국해양공학회지, 2020
A track-type underwater construction robot (URI-R) was developed by the Korea Institute of Ocean Science & Technology. Because URI-R uses tracks to move on the seabed, insufficient ground strength may hinder its movement. For smooth operation of URI-R on
Jung-min Seo, Changjoo Shin, OSoon Kwon, In Sung Jang, Hyoun Kang, Sung Gyu Won   +5 more
doaj   +1 more source

Penetration depth method - novel real-time strategy for evaluating femoroacetabular impingement

, 2010
We introduce a new method for computerized real-time evaluation of femoroacetabular impingement (FM). In contrast to previously presented stress analyses, this method is based on two types of predictions of penetration depths for two rotating bodies ...
Boulic, R, Tannast, M, Daniel Thalmann, Salman Chegini, Ehsan Arbabi, Thalmann, D, Thalmann, Daniel, Ronan Boulic, Chegini, S, Arbabi, Ehsan, Chegini, Salman, Tannast, Moritz, Ferguson, SJ, Ferguson, Stephen J., Stephen J. Ferguson, Boulic, Ronan, Arbabi, E, Moritz Tannast   +17 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source