Results 61 to 70 of about 2,766,525 (342)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Pair Correlation Influence on Superconductors Josephson Penetration Depth
Spektra: Jurnal Fisika dan AplikasinyaThe Josephson penetration depth is an essential characteristic of Josephson junctions, serving a role akin to the London penetration depth in bulk superconductors.
Yadhav Poudel +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Penetration depth time history measurement method [PDF]
, 2000 A new method for measuring the depth time history of rigid body penetration into brittle materials under a deceleration of ~10^5 g. The method includes: sabot-projectile, sabot-projectile separation and penetration depth detection systems.
Ahrens, T. J., Liu, C., C. Liu
core +1 more source
Photodiagnosis and Photodynamic TherapyObjectives: This study compared the effects of conventional, ultrasonic, and laser-activated irrigation (LAI) on penetration depth of three photosensitizers (PSs) in the root canal system.
Siavash Jafari Semnani +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Development mechanism of aging depth of bitumen with increasing UV aging time
Case Studies in Construction Materials, 2022 The UV aging of bitumen has a significant influence on the pavement service life, therefore, the research on UV aging has attracted increasing attention recently.
Yuanyuan Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Penetration of fastener projectiles into construction materials [PDF]
, 1988 The normal impact, penetration of both projectile and fastener into soils, rocks, and concrete at low velocities has been investigated using theoretical, experimental, and numerical approaches under axisymmetric conditions.
Zhou, Gang
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source