Results 51 to 60 of about 525,062 (269)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Cascaded Reinforcement Learning Agents for Large Action Spaces in Autonomous Penetration Testing

open access: yesApplied Sciences, 2022
Organised attacks on a computer system to test existing defences, i.e., penetration testing, have been used extensively to evaluate network security. However, penetration testing is a time-consuming process.
Khuong Tran   +6 more
doaj   +1 more source

Penetration testing model for mobile cloud computing applications / Ahmad Salah Mahmoud Al-Ahmad [PDF]

open access: yes, 2017
Mobile cloud computing (MCC) technology possess features mitigating mobile limitations and enhancing cloud services. MCC application penetration testing issues are complex and unique which make the testing difficult for junior penetration testers.
Mahmoud Al-Ahmad, Ahmad Salah
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Blade Sharpness and its Effect on the Testing of Body Armours [PDF]

open access: yes, 2002
Factors such as edge sharpness and tip sharpness have been identified by Horsfall,1 as keyvariables in the testing of stab and slash resistant armours.
Champion, Stephen M.   +3 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

PenQA: A Comprehensive Instructional Dataset for Enhancing Penetration Testing Capabilities in Language Models

open access: yesApplied Sciences
Large language models’ domain-specific capabilities can be enhanced through specialized datasets, yet constructing comprehensive cybersecurity datasets remains challenging due to the field’s multidisciplinary nature.
Xiaofeng Zhong   +2 more
doaj   +1 more source

ANALISIS LAYANAN KEAMANAN SISTEM KARTU TRANSAKSI ELEKTRONIK MENGGUNAKAN METODE PENETRATION TESTING

open access: yesIlkom Jurnal Ilmiah, 2019
Payment transactions developed along with technological developments, now days technology supports digital payment, each type of digital transaction has its own security services,  this study focus on the analysis of security services (confidentiality ...
Huzain Azis, Farniawati Fattah
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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