Results 71 to 80 of about 525,062 (269)

Investigation into the effect of uncertainty of CPT-based soil type estimation on the accuracy of CPT-based pile bearing capacity analysis [PDF]

, 2016
Cone Penetration Test (CPT or CPTu) is commonly used for estimating soil types and also for the geotechnical design of pile foundation. However, the level of agreement between the CPT-based soil types and the traditional identification of soil types ...
Bellis, Angela, Hamza, Omar
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Report on Phase 2.3, Investigation of Welded Highway Bridges. Project IHR-64 [PDF]

, 1973
The object of this investigation was to study the effect of internal flaws on the fatigue behavior of butt-welded connections in mild structural steel, the initiation of fatigue cracks from these flaws and the propagation rates of these cracks in the ...
Ekstrom, D.H., Munse, W.H.
core  

Refining the PoinTER “human firewall” pentesting framework [PDF]

, 2019
PurposePenetration tests have become a valuable tool in the cyber security defence strategy, in terms of detecting vulnerabilities. Although penetration testing has traditionally focused on technical aspects, the field has started to realise the ...
Archibald, Jacqueline M., Renaud, Karen
core   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Self-recording portable soil penetrometer [PDF]

, 1973
A lightweight portable penetrometer for testing soil characteristics is described. The penetrometer is composed of a handle, data recording, and probe components detachably joined together.
Campbell, G. E., Costes, N. C., Norton, R. H., Sturm, R. G.   +3 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Comparative Analysis of Penetration Testing Frameworks: OWASP, PTES, and NIST SP 800-115 for Detecting Web Application Vulnerabilities

Journal of Applied Informatics and Computing
Web application security faces increasingly complex challenges as digital architectures evolve, necessitating the selection of appropriate and effective penetration testing methods.
Muhamad Bunan Imtias, Khothibul Umam, Hery Mustofa, Moh Hadi Subowo   +3 more
doaj   +1 more source