Results 261 to 270 of about 159,023 (310)
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A shrinkage‐resistant hydrogel is developed to confer post‐fabrication shape fidelity. The hydrogel, based on recombinant spider silk protein eADF4(C16)‐RGD and collagen‐I, exhibits tunable mechanical properties and shrink‐resistance in the presence of fibroblasts as well as muscle cells.
Xuen J. Ng +10 more
wiley +1 more source
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, EarlyView.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche
Advanced Healthcare Materials, EarlyView.Hypoxia is a key factor in bone marrow physiology and hematopoietic stem cell behavior. Lower oxygen tension influences the secretion of vasculature‐derived hematopoietic regulatory factors and alters hematopoietic cell behavior in a conditioned medium hydrogel model of bone marrow. Cyclosporin A is used to mitigate normoxic stress during hematopoietic
Gunnar B. Thompson +3 more
wiley +1 more source
Advanced Materials, EarlyView.Stem cell spheroids, produced via a high‐throughput microfabrication technique, are transported within a vortex generated at the outlet channels of a cross‐slot millifluidic chip. For Reynolds number exceeding 170–200, intermittent high shear stresses applied to each spheroid within the vortex trigger a massive release of biologically active ...
Elliot Thouvenot +8 more
wiley +1 more source
Advanced Materials, EarlyView.An organic BTHG agent called OTBP with prominent crystallinity is developed. The resonant absorption at 433 nm and prominent crystallinity of OTBP enhance its BTHG efficiency when excited by a 1300 nm femtosecond laser. Tuning the size of OTBP nanocrystals based on Mie scattering theory successfully enables them to achieve high‐contrast muti‐organ ...
Lidong Du +12 more
wiley +1 more source
Advanced Materials, EarlyView.The development of hydrogel‐impregnated robust interlocking nano connector (HiRINC) aims to address stent migration by improving tissue adhesion and reducing mechanical mismatch in self‐expandable metallic stents (SEMSs). The network‐like porous layer of HiRINC enhances adhesion and energy dissipation, demonstrates through ex vivo and in vivo tests ...
Eunyoung Jeon +8 more
wiley +1 more source
Advanced Materials, EarlyView.Upconversion nanoparticle‐covalent organic framework core–shell particles provide enhanced contrast for optoacoustic imaging by leveraging the optical absorption of upconversion luminescence within the covalent organic framework matrix. Beyond their role as contrast agents, these particles enable customizable therapeutic agent loading and release, as ...
Dong Wook Kim +8 more
wiley +1 more source
Structured Light Projection Using Image Guide Fibers for In Situ Photo‐biofabrication
Advanced Materials, EarlyView.Light‐based biofabrication is typically performed with single wavelength light sources and within benchtop devices. This work demonstrates FaSt‐Light (Fiber‐assisted Structured Light) as a new approach to achieve multiwavelength image projection using flexible image guide fibers, which enables a variety of applications for in situ biofabrication ...
Parth Chansoria +8 more
wiley +1 more source
Penicillin and semisynthetic penicillins in dermatology [PDF]
Clinics in Dermatology, 2003 Penicillins are one of most important antibiotics groups. They are extremely effective and still widely used. Moreover, they are the drugs of choice for a large number of infectious diseases. Penicillins belong to the -lactam group, which also include cephalosporins, monobactams, and carbapenems.
Stojan Tonev +2 more
openaire +3 more sources