Refining fibroblast-to-cardiomyocyte transdifferentiation protocols to explore emergent self-organization in cardiac cultures. [PDF]
Turchaninova E +13 more
europepmc +1 more source
In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari +2 more
wiley +1 more source
Imported case of cholera from India: the first recorded in Bulgaria in over a century. [PDF]
Yordanova R, Pentchev E.
europepmc +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
Occult invasive group A streptococcal infection with rapid progression to pediatric intraorbital abscess: a case report. [PDF]
Liu Y +6 more
europepmc +1 more source
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann +12 more
wiley +1 more source
Short Segments of Electrospun Nanofibers Loaded with Curcumin Can Protect the Cells in Spheroids against Oxidative Stress. [PDF]
Meng Y, Hao M, Xia Y.
europepmc +1 more source
OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang +12 more
wiley +1 more source
Infection with the Endonuclear Symbiotic Bacterium <i>Holospora obtusa</i> Reversibly Alters Surface Antigen Expression of the Host <i>Paramecium caudatum</i>. [PDF]
Fujishima M.
europepmc +1 more source
Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch +4 more
wiley +1 more source

