Results 91 to 100 of about 43,593 (360)

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents

Journal of Biomedical Materials Research Part A, Volume 111, Issue 2, Page 185-197, February 2023., 2023
Abstract Type 1 diabetes (T1D) presents with two therapeutic challenges: the need to correct underlying autoimmunity and restore β‐cell mass. We harnessed the unique capacity of regulatory T cells (Tregs) and the T cell receptor (TCR) to direct tolerance induction along with tissue‐localized delivery of therapeutic agents to restore endogenous β‐cell ...
Gregory P. Marshall, Judit Cserny, Chun‐Wei Wang, Benjamin Looney, Amanda L. Posgai, Rhonda Bacher, Benjamin Keselowsky, Todd M. Brusko   +7 more
wiley   +1 more source

Penile Cancer [PDF]

Journal of the National Comprehensive Cancer Network, 2013
Squamous cell carcinoma of the penis represents approximately 0.5% of all cancers among men in the United States and other developed countries. Although rare, it is associated with significant disfigurement, and only half of the patients survive beyond 5 years.
Clark, Peter E, Spiess, Philippe E, Agarwal, Neeraj, Biagioli, Matthew C, Eisenberger, Mario A, Greenberg, Richard E, Herr, Harry W, Inman, Brant A, Kuban, Deborah A, Kuzel, Timothy M, Lele, Subodh M, Michalski, Jeff, Pagliaro, Lance, Pal, Sumanta K, Patterson, Anthony, Plimack, Elizabeth R, Pohar, Kamal S, Porter, Michael P, Richie, Jerome P, Sexton, Wade J, Shipley, William U, Small, Eric J, Trump, Donald L, Wile, Geoffrey, Wilson, Timothy G, Dwyer, Mary, Ho, Maria   +26 more
openaire   +5 more sources

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

In vitro assessment of varying peptide surface density on the suppression of angiogenesis by micelles displaying αvβ3 blocking peptides

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 111, Issue 2, Page 343-353, February 2023., 2023
Abstract Ligand targeted therapy (LTT) is a precision medicine strategy that can selectively target diseased cells while minimizing off‐target effects on healthy cells. Integrin‐targeted LTT has been developed recently for angiogenesis‐related diseases.
Neha Phani Bhushan, Trevor Stack, Evan A. Scott, Kenneth R. Shull, Benjamin Mathew, Divya Bijukumar   +5 more
wiley   +1 more source

Computational methods for cancer driver discovery: A survey [PDF]

arXiv, 2020
Motivation: Uncovering the genomic causes of cancer, known as cancer driver genes, is a fundamental task in biomedical research. Cancer driver genes drive the development and progression of cancer, thus identifying cancer driver genes and their regulatory mechanism is crucial to the design of cancer treatment and intervention.
arxiv  

An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]

, 2011
Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized by intricate interplay of molecular interactions.
arxiv   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26‐Week Results From the Phase 3 PaTHway Trial

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 14-25, January 2023., 2023
TransCon PTH is an investigational once‐daily prodrug providing sustained release of active PTH designed to maintain stable PTH levels in the physiological range for 24 hours/day. The PaTHway trial met all primary and key secondary endpoints with statistically significant differences from placebo. Most adverse events (AEs) were mild/moderate. Injection‐
Aliya A Khan, Mishaela R Rubin, Peter Schwarz, Tamara Vokes, Dolores M Shoback, Claudia Gagnon, Andrea Palermo, Claudio Marcocci, Bart L Clarke, Lisa G Abbott, Lorenz C Hofbauer, Lynn Kohlmeier, Susanne Pihl, Xuebei An, Walter Frank Eng, Alden R Smith, Jenny Ukena, Christopher T Sibley, Aimee D Shu, Lars Rejnmark   +19 more
wiley   +1 more source

Three facets of mathematical cancer biology research [PDF]

arXiv, 2023
Cancer, as the uncontrollable cell growth, is related to many branches of biology. In this review, we will discuss three mathematical approaches for studying cancer biology: population dynamics, gene regulation, and developmental biology. If we understand all biochemical mechanisms of cancer cells, we can directly calculate how the cancer cell ...
arxiv