Results 121 to 130 of about 17,826 (255)

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Input Visualizations to Track Health Data by Older Adults with Multiple Chronic Conditions

Computer Graphics Forum, EarlyView.
Abstract Older adults living with multiple chronic conditions (MCC) can considerably benefit from collecting and reflecting on their health data. Many older adults collect their health data using various approaches, such as digital tools or handwritten notebooks.
Shri Harini Ramesh, Foroozan Daneshzand, Matteo Sotelo, Mahsa Sinaei, Fateme Rajabiyazdi   +4 more
wiley   +1 more source

Neoadjuvant Treatment for Penile Cancer: A Systematic Review of Contemporary Evidence. [PDF]

Cancers (Basel)
Santucci J, Crisafi D, Sathianathen N, Eapen R, Bolton D, Murphy D, Lawrentschuk N, Perera M.   +7 more
europepmc   +1 more source

S1 guideline sweat gland carcinoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The current classification of sweat gland carcinomas is based on histomorphological characteristics and distinguishes between more than 20 entities. Most patients are older, but some subtypes also affect middle‐aged and younger patients. The majority of tumors arise de novo. Sweat gland carcinomas have nonspecific clinical features.
Mirjana Ziemer, Michael Erdmann, Abbas Agaimy, Jürgen C. Becker, Almut Böer‐Auer, Doris Helbig, Cornelia Erfurt‐Berge, Alexander Frisman, Conrad Hempel, Ulrike Leiter, Friedegund Meier, Thomas Mentzel, Lara Racz, Silke Redler, Stefan Schliep, Clemens Seidel, Alpaslan Tasdogan, Jochen Utikal, Carsten Weishaupt, Selma Ugurel   +19 more
wiley   +1 more source

Unveiling the variations in penile cancer care: identifying knowledge gaps and research priorities. [PDF]

BMJ Oncol
Prakash G, Arora A, Basile G, Mohanty S, Joshi A, Menon S, Shah H, Bandini M, Murthy V.   +8 more
europepmc   +1 more source

Representation of melanoma depth staging with limited central section sampling: a retrospective simulation study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives For thick melanomas, retaining the primary lesion during neoadjuvant therapy may enhance immune response through increased antigen load. This study assessed whether a central section from serially processed melanoma specimen, representing a transectional incisional biopsy, accurately reflects Breslow thickness and ...
Katharina Pustelnik, Philipp Tschandl
wiley   +1 more source

Organisational dehumanisation: Authoritativeness as remedy

European Management Review, EarlyView.
Abstract According to orthodoxy, the human relations movement was a watershed in rehumanising scientifically managed workplaces. In the wake of such purported reform, pundits (theorists and practitioners alike) have typically taken for granted that 21st century approaches to workplace superintendence, birthed in the wake of the Hawthorne Studies and ...
Jean‐Etienne Joullié, Anthony M. Gould, Jeffrey Muldoon   +2 more
wiley   +1 more source

Extracellular fluid viscosity influences the mechanics and migration of MDA‐MB‐231 cells in a macromolecule‐dependent manner

The FEBS Journal, EarlyView.
Macromolecule‐dependent increases in extracellular fluid viscosity alter cell phenotype. These distinct macromolecules create different extracellular environments that modulate cell morphology and mechanoprotein expression, migration and invasion capacity, and cellular mechanical properties.
Ian M. Smith, Nikka Givpoor, Chenchen Handler, Ariel Abraham, Shohini Banerjee, Giuliano Scarcelli, Kimberly M. Stroka   +6 more
wiley   +1 more source

A guide to laser microdissection‐based proteomics

The FEBS Journal, EarlyView.
This review takes researchers through the full laser microdissection proteomics workflow—from tissue preparation and image analysis to sample processing and mass spectrometry—offering practical solutions to common challenges at each step. Real‐world examples from across the field illustrate how the technology is being applied to disease tissue, making ...
Cheng Shen, Kael Schoffer, Charlotte Williams, Maria C. Tanzer   +3 more
wiley   +1 more source

Optimization of Analytical Performances and Routine Laboratory Implementation of NPM1 Mutation Detection by Digital PCR in the Diagnosis and Monitoring of NPM1‐Mutated Acute Myeloid Leukemias

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Quantification and monitoring of NPM1 mutations represent a key tool in the management of acute myeloid leukemia (AML), offering strong prognostic value and serving as a marker of minimal residual disease (MRD). Digital PCR (dPCR) provides absolute quantification with high sensitivity and specificity, offering advantages over ...
Chloé Ferrari, Brice Coulleray, Pauline Kerneves, Carole Geara, Dina Naguib, Guénaelle Levallet, Elizabeth Battersby, Sylvain Chantepie, Yohann Repessé, Coralie Nectoux, Elsa Maitre   +10 more
wiley   +1 more source