Results 171 to 180 of about 324,495 (340)
Advanced Science, EarlyView.Nanoplastics exposed to defined weathering conditions are systematically investigated as vectors for polycyclic aromatic hydrocarbons (PAHs). This investigation demonstrates significant potential for enhancing PAH uptake and transport in an intestinal membrane model.
Erik B. Schiferle +5 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
How Atypical Penile Curvature Influence Clinical Outcomes in Patients with Peyronie's Disease Receiving Collagenase Clostridium Histolyticum Therapy? [PDF]
World J Mens Health, 2020 Cocci A +13 more
europepmc +1 more source
Advanced Science, EarlyView.An edible and recyclable composite film composed of gelatin and activated charcoal is presented for multifunctional health and environmental monitoring. The edible films exhibit tuneable mechanical and electrical properties, along with multimodal sensing capabilities for strain, humidity, and temperature. The composite film is degradable and recyclable,
Ming Dong +6 more
wiley +1 more source
Advanced Science, EarlyView.The mechanism diagram reveals that the formation of trauma‐induced heterotopic ossification (HO) is accompanied by the polarization of macrophages toward the M1 phenotype. Additionally, the extracellular vesicles secreted by M1 macrophages, which contain periostin (POSTN), directly bind to PTK7 in tendon‐derived stem cells (TDSCs).
Hang Liu +9 more
wiley +1 more source
CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade
Advanced Science, EarlyView.This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou +15 more
wiley +1 more source
MP43-01 REAL AND PERCEIVED MAGNITUDE OF CURVATURE AMONG PATIENTS AFFECTED BY PENILE CURVATURE: ACQUIRED PENILE CURVATURE (APC) VS CONGENITAL PENILE CURVATURE (CPC) ARE THERE ANY DIFFERENCES? [PDF]
Journal of Urology, 2015 Gaetano Chiapparrone +6 more
openaire +2 more sources
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Advanced Science, EarlyView.Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai +13 more
wiley +1 more source