Results 101 to 110 of about 18,088 (262)

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source

Penile Ulcer in Crohn's Disease [PDF]

Journal of the Royal Society of Medicine, 1984
openaire   +2 more sources

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Novel erectile analyses revealed augmentable penile Lyve‐1, the lymphatic marker, expression

Reproductive Medicine and Biology
Purpose The pathophysiology of penis extends to erectile dysfunction (ED) to conditions including sexually transmitted diseases (STDs) and cancer. To date, there has been little research evaluating vascular drainage from the penis.
Kota Fujimoto, Daiki Hashimoto, Sang Woon Kim, Yong Seung Lee, Takuya Suzuki, Masanori Nakata, Shinji Kumegawa, Shinichi Asamura, Gen Yamada   +8 more
doaj   +1 more source

Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen—A Case Report and Literature Review

Diagnostic Cytopathology, EarlyView.
ABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
William H. Wu, Joanna K. M. Ng, Joshua J. X. Li   +2 more
wiley   +1 more source

Photothermal bubble: Dynamics, manipulation, and applications

Droplet, EarlyView.
As a versatile platform for bubble manipulation, photothermal techniques empower diverse operations: planar translation by scanning the laser spot, sustained periodic bouncing from competing thermal and hydrodynamic flows, and even guided 3D trajectories achieved by tailoring the heating configuration.
Man Hu, Feng Wang, Daosheng Deng
wiley   +1 more source

Feasibility of partial penectomy under local anesthesia: a case–control study

African Journal of Urology
Background To assess the feasibility of partial penectomy under local anesthesia and penile nerve blocks. Methods A total of 45 patients underwent partial penectomy under local anesthesia over the last 15 years at our institute.
Madhur Anand, Apul Goel, Bhupendra Pal Singh, Swati Aggarwal, Manoj Kumar, Vivek Kumar Singh, Vishwajeet Singh   +6 more
doaj   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source