CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade
Advanced Science, EarlyView.This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou +15 more
wiley +1 more source
(58) “THE COMBINATION OF PRP AND STEM CELLS IMPROVES ERECTILE FUNCTION AFTER PENILE RESTORATION FOR PEYRONIE'S DISEASE WITH GRAFTS” [PDF]
, 2023 Fliatouras Dr. Christos +3 more
openalex +1 more source
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Advanced Science, EarlyView.Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai +13 more
wiley +1 more source
MP10-06 SURGICAL TREATMENT OF PRIMARY DISEASE FOR PENILE SQUAMOUS CELL CARCINOMA: A SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) DATABASE ANALYSIS [PDF]
, 2015 Weijie Gu, Yao Zhu, Dingwei Ye
openalex +1 more source
Advanced Electronic Materials, EarlyView.The single‐molecule with a large transistor‐SiMoT is proposed for the detection of the subgenomic RNA of SARS‐CoV‐2, achieving a diagnostic sensitivity of 98.0% and a specificity of 87.8%. The SiMoT technology, currently at TRL‐5, is suitable for point‐of‐care settings and delivers the result to the end user in 30 min.
Eleonora Macchia +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.We report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Antoine Schlichter +29 more
wiley +2 more sources
PD45-06 SUPERIOR COST EFFECTIVENESS OF PENILE PLICATION VERSUS INTRALESIONAL COLLAGENASE INJECTION FOR TREATMENT OF PEYRONIE’S DISEASE DEFORMITIES [PDF]
, 2016 Billy H. Cordon +5 more
openalex +1 more source
Outcomes of RestoreX Penile Traction Therapy in Men with Peyronie’s Disease: Results from Open Label and Follow-Up Phases [PDF]
, 2020 Jason Joseph +5 more
openalex +1 more source
Advanced Energy Materials, EarlyView.The review highlights the multifunctional capabilities of thermoelectric sensors integrated with advanced features such as biocompatibility, advanced integration, self‐healing, and environmental adaptability. Emphasizing sustainability and adaptability, these sensors offer enhanced durability, increased efficiency, reduced waste, and seamless ...
Neeraj Dhariwal +9 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source