Results 91 to 100 of about 555,805 (243)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Human Papilloma Virus: Prevalence, distribution and predictive value to lymphatic metastasis in penile carcinoma

International Brazilian Journal of Urology, 2013
Objectives To evaluate the prevalence, distribution and association of HPV with histological pattern of worse prognosis of penile cancer, in order to evaluate its predictive value of inguinal metastasis, as well as evaluation of other previous reported ...
Aluizio Goncalves da Fonseca, Fernando Augusto Soares, Rommel Rodriguez Burbano, Rodrigo Vellasco Silvestre, Luis Otavio Amaral Duarte Pinto   +4 more
doaj   +1 more source

Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers [PDF]

, 2015
Background: Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an important public health issue for poor and developing countries.
Ademar Lopes, Ariane Fidelis Busso, Cristovam Scapulatempo-Neto, Eliney Ferreira Faria, Fabio Albuquerque Marchi, Gustavo Cardoso Guimarães, Hector Hernandez-Vargas, Hellen Kuasne, Ilce Mara de Syllos Cólus, Mateus Camargo Barros-Filho, Silvia Regina Rogatto, Zdenko Herceg   +11 more
core   +2 more sources

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source

SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer

Human Genomics, 2023
Background The effect of SPP1 in squamous cell carcinoma of the penis (PSCC) remained unknown. We attempted to clarify the function of the SPP1 gene in PSCC.
Yuantao Zou, Xingliang Tan, Gangjun Yuan, Yi Tang, Yanjun Wang, Cong Yang, Sihao Luo, Zhiming Wu, Kai Yao   +8 more
doaj   +1 more source

Hubungan Ekspresi P-53 Dengan Gambaran Klinikopatologi Pada Penderita Karsinoma Penis Yang Dirawat Di Rumah Sakit Sanglah, Denpasar (2001-2005) [PDF]

, 2009
Insiden karsinoma penis di daerah Bali, khususnya yang dirawat di Rumah Sakit Sanglah, cukup tinggi. Sampai saat ini, etiologi dari karsinoma penis multifaktorial, termasuk peran Human Papilloma Virus dalam mekanisme di tingkat selular.
Kusuma, G. W. (Gede), Partama, P. (Partama), Sastrodihardjo, B. (Bowolaksono)   +2 more
core  

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Cutaneous metastasis from penile squamous cell carcinoma resembling carcinoma en cuirasse [PDF]

, 2015
Penile squamous cell carcinoma is a rare malignancy seen more frequently in developing nations. Metastasis occurs in a predictable manner, with superficial lymph node involvement occurring first, followed by deep lymph node involvement, and then distant ...
Brady, Kimberly L, Gilmore, Elaine S, Scott, Glynis A   +2 more
core   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Ulcerated Nodal Metastasis in Penile Carcinoma

Open Journal of Urology, 2011
A 35 year old male patient presented with untreated ulcerative lesion over the penis of one year duration with ulcerations over bilateral groin and suprapubic areas of three months duration. Biopsy was reported as squamous cell carcinoma. Involvement of nodes along suprapubic area is rare and is found ulcerated in this case.
Krishnamachar Harish, Yagachikatte Chikkanarasaiah Madhu   +1 more
openaire   +2 more sources