Results 101 to 110 of about 555,805 (243)

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

Advanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye, Jianfeng Xiang, Siqi Zhou, Qintao Ge, Aihetaimujiang Anwaier, Kun Chang, Gang Wei, Jiahe Lu, Xi Tian, Shuxuan Zhu, Yuchen Jiang, Wei Zhang, Tingting Cai, Moran Xu, Dingwei Ye, Danfeng Xu, Tao Wang, Hailiang Zhang, Wenhao Xu   +18 more
wiley   +1 more source

A challenging diagnosis of penile sarcomatoid squamous cell carcinoma [PDF]

, 2019
We report a patient with penile sarcomatoid squamous cell carcinoma (SCC) initially misdiagnosed as condyloma acuminatum. Sarcomatoid SCC is a rare, aggressive, biphasic cancer that often presents a diagnostic challenge and carries a poor prognosis ...
Bunimovich, Yuri, Cardis, Michael, Ho, Jonhan, Jedrych, Jaroslaw, Khosravi, Hasan, Zhang, Sophia   +5 more
core  

Determination of Oncogenic Human Papillomavirus (HPV) Genotypes in Anogenital Cancers in Myanmar [PDF]

, 2016
Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identified oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in ...
Aye Aye Myint,, Hlaing Myat Thu,, Khin Khin Oo,, Khin Sandar Aye,, Khin Saw Aye,, Khin Shwe Mar,, Kyaw Zin Thant,, Mu Mu Shwe,, Mya Thida,, Shigeru Okada,   +9 more
core   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Centrosome clustering and Cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors [PDF]

, 2010
Background: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor.
A Valent, Antoni Gelabert, B Rebacz, BM Zaharieva, C Jin, C Lengauer, C Morales, CJ Nelsen, CJ Ormandy, D Hanahan, E Prat, Esther Prat, F Gergely, F Jiang, F Kuttler, Ferran Algaba, G Sauter, GA Pihan, GA Pihan, H Nakamura, H Rajagopalan, H Roelofs, I Fadl-Elmula, Immaculada Ponsa, Javier del Rey, JI Epstein, Jordi Camps, Josep Lloreta, K Kawamura, K Kawamura, LA Moreau, M Debatisse, M Schwab, ME Ewen, MJ Singer, NJ Ganem, NJ Quintyne, NS Chandhok, OP Kallioniemi, PP Bringuier, R Basto, R Hui, Rosa Miró, S O'Neill, SL Thompson, SS Andersen, V Narayanan, VM Draviam, Y Jin, Y Jin, Y Yamamoto   +50 more
core   +5 more sources

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Molecular functional imaging in an unusual case of penile metastasis

Cancer Research, Statistics, and Treatment, 2020
Carcinoma rectum has a favorable prognosis and good survival rate compared to other common cancers such as breast and lung. However, the undifferentiated histological type of rectal cancer is known for early and disseminated metastasis which ...
A. Mahajan, G. Santhosh Kumar, Tanvi Vaidya, Anurag Gupta, A. Agrawal, A. Saklani, R. Engineer, V. Otswal, S. Arya   +8 more
semanticscholar   +1 more source

Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw‐Rod external fixation

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that using a Pedicle screw‐Rod configuration for the external fixation of non‐articular tibial osteotomy aligns well with the principles of biological osteosynthesis, resulting in secondary bone healing characterized by callus formation and neovascularization.
Mohammad Mahdi Gooran, Ramin Mazaheri‐Khameneh, Seyed Mohammad Hashemi‐Asl, Rahim Hobbenaghi   +3 more
wiley   +1 more source

Malignant melanoma of the penis and urethra: one case report [PDF]

, 2014
We present a case of a patient with malignant melanoma of the glans penis and urethra, which was found in a 53-year-old man with nonhealing ulcerative penile lesion and bilateral, clinically palpable inguinal lymphadenopathies at diagnosis.
Anguo Wang, Haichao Yuan, Ji Wu, Qiang Wei, Yunxiang Li, Zongping Zhang   +5 more
core   +1 more source

Measuring the Impact of the Substitution of Innovator Biologics With Biosimilars on Uptake and Costs Among Ontario Public Drug Benefit Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
In Ontario, biologics have historically represented a small proportion of public drug claims but a large proportion of spending. Biosimilars, lower cost alternatives to biologics, offer a potential solution to the rising spending on biologics. From March 2023 to January 2024, the Ontario Ministry of Health required public drug program beneficiaries on ...
Anita Iacono, Martin K. H. Ho, Joanna Yang, Tonya Campbell, William Wynne, Dana Shearer, Lene Andersen, Eric Majer, Shaleesa Ledlie, Mina Tadrous, Tara Gomes   +10 more
wiley   +1 more source