Results 91 to 100 of about 7,326 (312)

Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression

Advanced Science, EarlyView.
A novel strategy combining borate glass and ultrasound is proposed for the precise treatment of breast cancer. The locally delivered borate glass releases Ca2⁺ ions in situ, while ultrasound activates the highly expressed transient receptor potential vanilloid 2 channels in breast cancer cells. This synergistic effect induces specific calcium overload,
Haihong Zhu, Liping Ouyang, Yangguang Huang, Ji Tan, Chunyu Liu, Qian Wang, Rongkun Huang, Wing Tak Wong, Xuanyong Liu, Haobo Pan, Yun Liao   +10 more
wiley   +1 more source

Prognostic Factors for Penile Cancer and Survival in Response to Multimodality Therapy

Research and Reports in Urology, 2020
Wichien Sirithanaphol,1 Aumkhae Sookprasert,2 Ukrit Rompsaithong,1 Pakorn Kiatsopit,1 Kosin Wirasorn,2 Jarin Chindaprasirt2 1Division of Urologic Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Division of
Sirithanaphol W, Sookprasert A, Rompsaithong U, Kiatsopit P, Wirasorn K, Chindaprasirt J   +5 more
doaj  

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Outermost Cationic Surface Charge of Layer‐by‐Layer Films Prevents Endothelial Cells Migration for Cell Compartmentalization in Three‐Dimensional Tissues

Advanced Science, EarlyView.
A nanometer‐sized artificial basement membrane (A‐BM) is developed to replicate the barrier functions of the basement membrane and prevent cell migration. It is demonstrated that the outermost cationic surface charge of nanofilms can effectively inhibit endothelial cell migration and sprouting, allowing for the construction of 3D patterned vascular ...
Jinfeng Zeng, Sven Heilig, Matthias Ryma, Jürgen Groll, Congju Li, Michiya Matsusaki   +5 more
wiley   +1 more source

IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice

Andrology, Volume 11, Issue 2, Page 358-371, February 2023., 2023
Abstract Background The incidence of diabetic erectile dysfunction (ED) is rapidly increasing, and due to the severe angiopathy caused by diabetes, current drugs are ineffective at treating ED. Insulin‐like growth factor‐binding protein 5 (IGFBP5) promotes cell death and induces apoptosis in various cell types.
Jiyeon Ock, Jun‐Kyu Suh, Soon‐Sun Hong, Ju‐Hee Kang, Guo Nan Yin, Ji‐Kan Ryu   +5 more
wiley   +1 more source

Penile Skin as a Rare Location of Melanoma in the Balkan Region: A Case Report

Acta Médica Portuguesa
Skin melanoma is very rarely found in the genital region. Additionally, out of all penile skin malignancies, melanoma is one of the rarest, with no cases reported before in the Balkan region.
Jasna Gacic, Aleksandar Lazarov, Marijana Lazarov Bandic, Jadran Bandic, Srdjan Nikolovski, Marko Nikolic   +5 more
doaj   +1 more source

Interview with the World Class Authorities Frontiers of Cancer Research: An exclusive interview with Professor Luis Diaz

Annals of Gastroenterological Surgery, EarlyView.
This is the second installment in the series, “The Interview with the World‐Class Authorities.” We are honored to welcome Prof. Luis Diaz, the Director of the Division of Solid Tumor Oncology at Memorial Sloan Kettering Cancer Center and Editor‐in‐Chief of Cancer Discovery. Prof.
Haruna Takeda, Koshi Mimori, Masanobu Oshima, Ken Shirabe, Yuko Kitagawa   +4 more
wiley   +1 more source

Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

Andrology, Volume 11, Issue 2, Page 379-398, February 2023., 2023
Abstract Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million.
Ankit Desai, Runzhi Chen, Axel Cayetano, Channa N. Jayasena, Suks Minhas   +4 more
wiley   +1 more source

Penile squamous cell carcinoma and lichen planus

Surgical and Experimental Pathology, 2020
Background Penile squamous cell carcinoma (PSSC) has some non-PHV associated precursos and lichen planus is not considered one of them. Case presentation A 78-year-old patient sought the urologist due to a history of erythema on glans for 12 months and ...
Marcos Lima de Oliveira Leal, Lucas Rosemberg Pellegrino Jorge Alencar, Suelen Cunha Santana, Bianca Carla Azevedo de Souza, Daniel Abensur Athanazio   +4 more
doaj   +1 more source

Dietary Qiwenghuangbo powder–enriched Limosilactobacillus reuteri protects the intestinal epithelium and alleviates inflammation via a strain‐specific mechanism

Animal Models and Experimental Medicine, EarlyView.
Dietary Qiwenghuangbo powder improved growth performance and intestinal health of weaned piglets, as well as altered microbiota composition as significant enrichment of Limosilactobacillus reuteri. Furthermore, out of three isolated L. reuteri, two strains could alleviate pathogen infection and intestinal inflammation in the colitis models induced by ...
Qian Xu, Lei Xue, Zhenhua Wu, Shuaishuai Kang, Jia Li, Yifan Wu, Yujun Wu, Jinbiao Zhao, Rujuan Wu, Huiyuan Lv, Junjun Wang, Dandan Han   +11 more
wiley   +1 more source