Results 101 to 110 of about 11,733 (324)

Use of rectal mucosal grafts in substitution urethroplasty: an early series [PDF]

, 2018
Background: To evaluate the feasibility of use of rectal mucosal grafts for augmentation urethroplasty. Methods: A series of five patients who underwent rectal mucosal graft urethroplasty for urethral stricture disease were identified. Descriptive
Mellon, Matthew J., Monn, M. Francesca, Waters, Joshua A.   +2 more
core   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

Penile metastasis from primary cholangiocarcinoma: the first case report [PDF]

, 2013
BACKGROUND: Metastatic penile carcinoma derived from cholangiocarcinoma (CCA) has not been previously reported in the literature. Common metastatic sites for CCA include the regional lymph nodes and adjacent organs.
Andrea Fuschi, Antonio Carbone, Antonio Luigi Pastore, Carlo Della Rocca, Claudio Di Cristofano, Cristina Maggioni, Davide Moschese, Domenico Alvaro, Domenico De Santis, Giorgia Manfredonia, Giovanni Palleschi, Natale Porta, Piero Maceroni, Simone Ferretti, Vincenzo Petrozza, Yazan Al Salhi   +15 more
core   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Tumor histologic grade is the most important prognostic factor in patients with penile cancer and clinically negative lymph nodes not submitted to regional lymphadenectomy

International Brazilian Journal of Urology
Introduction: The presence and extension of inguinal lymph node metastasis are the main prognostic factors in patients with penile cancer. Physical exam and image exams are not adequate to evaluate inguinal lymph nodes and many patients are submitted to ...
Giuliano Amorim Aita, Stênio de Cássio Zequi, Walter Henriques da Costa, Gustavo Cardoso Guimarães, Fernando Augusto Soares, Thais Safranov Giuliangelis   +5 more
doaj   +1 more source

Conservative management for postprostatectomy urinary incontinence [PDF]

, 2015
BACKGROUND: Urinary incontinence is common after radical prostatectomy and can also occur in some circumstances after transurethral resection of the prostate (TURP).
Abbinante, Aboseif, Abrams, Ahmed, Albertsen, Altman, Bales, Berghmans, Berghmans, Bocker, Burgio, Burgio, Burkert, Burnett, Campbell, Centemero, Centemero, Chang, Chao, Cornel, Cornu, Crevenna, Crivellaro, Crivellaro, Delmastro, Dieperink, Dijkstra-Eshuis, Donnellan, Dorey, Dorey, Dubbelman, Dubbelman, Dubbelman, Dubbelman, Eastham, Eren, Eren, Fader, Fader, Fader, Ficazzola, Filocamo, Filocamo, Foratos, Franke, Franke, Galloway, Geraerts, Glazener, Glazener, Glazener, Glazener, Glazener, Glazener, Golubuff, Goode, Goode, Grise, Groutz, Gudziak, Guyatt, Guyatt, Guyatt, Guyatt, Hagen, Hagen, Higgins, Hoffmann, Hotston, Hou, Hunter, Hunter, Ip, Jabs, Jacobsen, Jahn, Joseph, Juni, Kahihara, Kampen, Kampen, Kampen, Khan, Kim, Koo, Laurienzo, Leach, Lilli, Lin, Liu, MacDonald, Majoros, Manassero, Marchiori, Mariotti, Martini, Mathewson-Chapman, Mathewson-Chapman, McCammon, McGlynn, McGuire, Milsom, Mishel, Moore, Moore, Moore, Moore, Moore, Moore, Moore, Moore, Morihiro, Morkved, Niël-Weise, Nowak, Omar, Opsomer, Ottenbacher, Overgard, Parekh, Park, Park, Pemberton, Peyromaure, Popolo, Porru, Prota, Rainwater, Rassweiler, Ribeiro, Ribeiro, Ribiero, Ricci, Robinson, Robinson, Robinson, Sacco, Sacco, Salinas Casado, Salinas Casado, Sciarra, Sciarra, Shen, Silva, Simeit, Sueppel, Thompson, Tibaek, Tibaek, Tienforti, Tobia, Traeger, Turner, Uebersax, Update Buckley, Update Buckley, Update Glazener, Update Glazener, Update Nilssen, Voorham-Van Der Zalm, Ware, Wille, Wille, Wilson, Winters, Yamanishi, Yamanishi, Yang, Yao, Yokoyama, Zahariou, Zellner, Zermann, Zhang, Zhang, Zhang, Zhang, Zopf   +177 more
core   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Glomus tumor of penis- A rare case [PDF]

, 2013
Glomus tumors are rare, painful, and benign soft tissue tumors of the skin arising from the glomus body, an arteriovenous thermoregulatory structure. This lesion is usually found on the extremities.
Madhuri S. Kate, Preeti Jain, Sushma Gulhane   +2 more
core  

Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil [PDF]

, 2003
This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed
Amaral, Rita Goreti, Magalhães, Albino Verçosa de, Santos, Silvia Helena Rabelo dos, Sobrinho, João Simão Pereira, Villa, Luisa Lina, Zeferino, Luiz Carlos   +5 more
core   +4 more sources

POSTN‐Mediated Interplay of M1 Polarized Macrophage with Tendon‐Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Advanced Science, EarlyView.
The mechanism diagram reveals that the formation of trauma‐induced heterotopic ossification (HO) is accompanied by the polarization of macrophages toward the M1 phenotype. Additionally, the extracellular vesicles secreted by M1 macrophages, which contain periostin (POSTN), directly bind to PTK7 in tendon‐derived stem cells (TDSCs).
Hang Liu, Xinyue Li, Mengyi Li, Ziyang Sun, Xu Wang, Juehong Li, Binbin Xu, Qian Chen, Cunyi Fan, Hongjiang Ruan   +9 more
wiley   +1 more source