Results 121 to 130 of about 5,528 (259)

Renal clearance of fluorescent agents can compromise image‐guided surgery along the urinary tract

BJU International, EarlyView.
Objectives To study the effect of renally cleared fluorescent agents on image‐guided surgery along the urinary tract by using the renally cleared, non‐tumour‐specific, fluorescent dye fluorescein. Subjects and Methods Sixteen patients who underwent robot‐assisted radical prostatectomy (RARP) with lymph node dissection received an intradermal injection ...
Anne‐Claire Berrens, Tessa Buckle, Matthias N. van Oosterom, Leon J. Slof, Belle M. Melsert, Jakko A. Nieuwenhuijzen, Esther M.K. Wit, Pim J. van Leeuwen, Henk G. van der Poel, Fijs W.B. van Leeuwen   +9 more
wiley   +1 more source

The association of smoking with urinary and sexual function recovery following radical prostatectomy

BJU International, EarlyView.
Objective To investigate the association of smoking with post‐prostatectomy functional recovery in a large population‐based cohort using standardised outcome measures. Patients and Methods We conducted a cohort study and reported findings according to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines.
Jordi Visscher, Billie Bonevski, Michael O'Callaghan   +2 more
wiley   +1 more source

Pediatric brain tumor classification using digital pathology and deep learning: Evaluation of SOTA methods on a multi‐center Swedish cohort

Brain Pathology, EarlyView.
Deep learning‐based feature extractors pretrained on histopathology images can classify pediatric brain tumors when applied to a multi‐center Swedish dataset. Abstract Brain tumors are the most common solid tumors in children and young adults, but the scarcity of large histopathology datasets has limited the application of computational pathology in ...
Iulian Emil Tampu, Per Nyman, Christoforos Spyretos, Ida Blystad, Alia Shamikh, Gabriela. Prochazka, Teresita Díaz de Ståhl, Johanna Sandgren, Peter Lundberg, Neda Haj‐Hosseini   +9 more
wiley   +1 more source

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

British Journal of Pharmacology, Volume 182, Issue 15, Page 3669-3687, August 2025.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia, Belén Climent, Bianca Barreira, Daniel Morales‐Cano, Ana Sánchez, Argentina Fernández, Borja García‐Gómez, Javier Romero‐Otero, Claudia Rodríguez, Laura Moreno, Dolores Prieto, María Jesús Larriba, Angel Cogolludo, Javier Angulo, Francisco Perez‐Vizcaino   +14 more
wiley   +1 more source

Deep Phenotyping of Pathology‐Confirmed Benign Lesions in PTEN Hamartoma Tumor Syndrome Patients

Clinical Genetics, EarlyView.
Gastrointestinal, skin, thyroid, and vascular lesions are frequently present in PTEN Hamartoma Tumor Syndrome patients with little to no difference between sexes or by index status. Early‐onset lipomas (< 20 years) may be useful for early recognition of patients, and uterine polyps should be considered for inclusion as a PHTS‐related lesion.
Ane J. Schei‐Andersen, Janneke H. M. Schuurs‐Hoeijmakers, Rachel van der Post, Arjen R. Mensenkamp, Jolanda Schieving, PTEN Study Group, Muriel A. Adank, Mirjam de Jong, Marjolijn C.J. Jongemans, Liselotte P. van Hest, Yvette van Ierland, Edward M. Leter, Maartje Nielsen, Janet R. Vos, Nicoline Hoogerbrugge   +14 more
wiley   +1 more source

NSun2‐Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation

Cell Proliferation, EarlyView.
NSun2 deficiency inhibited sinusoidal capillarization, alleviating liver fibrosis. Reduced NSun2 expression led to alterations in the functional tsRNAs tRF‐1‐S25 and tRF‐5‐V31, which regulate sinusoidal capillarization by targeting key proteins, including DUSP1 and FAK – crucial clinical targets – offering a novel RNA‐based therapeutic approach for ...
Pengcheng Li, Sunyang Ying, Yu Zou, Xin Wang, Runxue Zhang, Cheng Huang, Moyu Dai, Kai Xu, Guihai Feng, Xin Li, Haiping Jiang, Zhikun Li, Ying Zhang, Wei Li, Qi Zhou   +14 more
wiley   +1 more source

PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region. [PDF]

Oncotarget
Carneiro HC, Natal RA, Vassallo J, Soares FA.   +3 more
europepmc   +1 more source

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25

The FEBS Journal, EarlyView.
Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found that the small GTPase Rab25 promoted the expression of ADAMTS5 in ovarian cancer cells through the activation of the NF‐κB signalling pathway.
Shengnan Yuan, Rachele Bacchetti, Jamie Adams, Doretta Cuffaro, Armando Rossello, Elisa Nuti, Salvatore Santamaria, Elena Rainero   +7 more
wiley   +1 more source

Risk of Vulvar HSIL and Penile Neoplasias in Anogenital Lichen Planus: A Case-Control Study. [PDF]

J Low Genit Tract Dis
Hieta NK, Tapana L, Söderlund JM, Huvila JK, Talve LAI, Haataja MAM.   +5 more
europepmc   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source