Results 191 to 200 of about 9,528 (278)

Designing the Next Generation of Biomaterials through Nanoengineering

open access: yesAdvanced Materials, Volume 37, Issue 39, October 2, 2025.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr.   +3 more
wiley   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk   +8 more
wiley   +1 more source

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang   +12 more
wiley   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou   +15 more
wiley   +1 more source

Differences in inflammatory markers, mitochondrial function, and synaptic proteins in male and female Alzheimer's disease post mortem brains

open access: yesAlzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Inflammation and mitochondrial impairments are suggested to underlie Alzheimer's disease (AD) development. This study examined whether metabolic, synaptic, and inflammatory markers in AD differed from non‐demented brains.
Alex J. T. Yang   +11 more
wiley   +1 more source

Retrospective clinical and molecular characterisation of patients with penile intraepithelial neoplasia. [PDF]

open access: yesBJU Int
Elbæk SK   +6 more
europepmc   +1 more source

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