Results 1 to 10 of about 135,803 (340)

Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors. [PDF]

PLoS ONE, 2016
BACKGROUND:Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that pentobarbital binds to some of the same sites where propofol and etomidate act.
Alexis M Ziemba, Stuart A Forman
doaj   +2 more sources

Stability of Sodium Pentobarbital 5w/v% Aqueous Solution During Short‐Term Chilled and Ambient‐Temperature Storage [PDF]

Veterinary Medicine and Science
The COVID‐19 pandemic made it difficult to obtain pharmaceutical‐grade injectable anaesthetics used in animal experiments in Japan. To address this problem, it is worth the effort to evaluate whether the use of non‐pharmaceutical‐grade sodium ...
Masakazu Dohi, Kayoko Ueda, Yoshinori Yamagiwa, Atsuko Yamashita, Yuji Sakamoto   +4 more
doaj   +2 more sources

Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex

Journal of Pharmacological Sciences, 2011
.: In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300
Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara   +9 more
doaj   +2 more sources

The effect of different immobilization approaches on red-eared sliders [PDF]

Scientific Reports
The ethical issues surrounding sacrifice methods in animal experimentation have garnered increasing attention, making immobilization and sedation an integral part of the sacrifice process for experimental animals.
Xin Niu, Nuo Xu, Chengyu Cui, Shuangyan Wang, Zhenyang Yu, Haitao Shi, Meiling Hong, Li Ding   +7 more
doaj   +2 more sources

Effects of Anesthesia with Pentobarbital/Ketamine on Mitochondrial Permeability Transition Pore Opening and Ischemic Brain Damage [PDF]

Biomedicines
Background and Objective: The alteration of mitochondrial functions, especially the opening of the mitochondrial permeability transition pore (mPTP), has been proposed as a key mechanism in the development of lesions in cerebral ischemia, wherefore it is
Evelina Rekuviene, Laima Ivanoviene, Vilmante Borutaite, Ramune Morkuniene   +3 more
doaj   +2 more sources

Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report [PDF]

Journal of Neurocritical Care, 2023
Background Barbiturate poisoning is rare but potentially fatal. Case Report We reported a case of barbiturate poisoning in a 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning.
Amélie Giudicelli-Bailly, Chiara Della Badia, Marc Augsburger, Hervé Quintard, Raphaël Giraud, Pia De Stefano   +5 more
doaj   +1 more source

Thermal Response of Laboratory Rats (Rattus norvegicus) during the Application of Six Methods of Euthanasia Assessed by Infrared Thermography

Animals, 2023
Refinement is one of the principles aiming to promote welfare in research animals. The techniques used during an experimental protocol, including euthanasia selection, must prevent and minimize suffering.
Adriana Domínguez-Oliva, Ismael Hernández-Ávalos, Adriana Olmos-Hernández, Juan Villegas-Juache, Antonio Verduzco-Mendoza, Daniel Mota-Rojas   +5 more
doaj   +1 more source

Case report: Fatal poisoning caused by additive effects of two barbiturates

Frontiers in Pharmacology, 2023
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 ...
Sella Takei, Hiroshi Kinoshita, Mostofa Jamal, Mitsuru Kumihashi, Tadayoshi Yamashita, Etsuko Tanaka, Sachiko Kawahara, Hiroko Abe, Kunihiko Tsutsui, Shoji Kimura   +9 more
doaj   +1 more source

A Comparison of Epileptogenic Effect of Status Epilepticus Treated With Diazepam, Midazolam, and Pentobarbital in the Mouse Pilocarpine Model of Epilepsy

Frontiers in Neurology, 2022
Status epilepticus (SE) is a medical emergency associated with acute severe systemic damage and high mortality. Moreover, symptomatic SE is one of the highest risk factors for epileptogenesis.
Xiangzhen Tong, Zizhu Zhang, Jianping Zhu, Shuji Li, Shaogang Qu, Bing Qin, Yanwu Guo, Rongqing Chen, Rongqing Chen, Rongqing Chen   +9 more
doaj   +1 more source

Review of Intraperitoneal Injection of Sodium Pentobarbital as a Method of Euthanasia in Laboratory Rodents.

Journal of the American Association for Laboratory Animal Science, 2020
Euthanasia is one of the most commonly performed procedures in biomedical research, involving tens of millions of animals in North America and Europe every year.
Colin A Laferriere, D. Pang
semanticscholar   +1 more source