Results 1 to 10 of about 147,283 (318)

Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors. [PDF]

PLoS ONE, 2016
BACKGROUND:Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that pentobarbital binds to some of the same sites where propofol and etomidate act.
Alexis M Ziemba, Stuart A Forman
doaj   +2 more sources

Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice [PDF]

Drug Metabolism And Disposition, 2020
NF-E2–related factor 2 (Nrf2) is a transcriptional regulator of biologic defense proteins, such as antioxidant proteins and phase II detoxification enzymes.
Takashi Ashino, Masayuki Yamamoto, Satoshi Numazawa   +2 more
openalex   +2 more sources

Autonomic and cardiovascular effects of pentobarbital anesthesia during trigeminal stimulation in cats [PDF]

International Journal of Oral Science, 2012
Stimulation of the trigeminal nerve can elicit various cardiovascular and autonomic responses; however, the effects of anesthesia with pentobarbital sodium on these responses are unclear.
Hiroshi Hanamoto, Hitoshi Niwa, Mitsutaka Sugimura, Yoshinari Morimoto   +3 more
openalex   +2 more sources

Sevoflurane, as opposed to pentobarbital anesthesia, attenuates LPS-induced myocardial injury by up-regulating TAF1D [PDF]

Scientific Reports
Septic cardiomyopathy (SCM) is a prevalent and severe complication associated with sepsis. This study explores the effects of sevoflurane and pentobarbital on lipopolysaccharide (LPS) -induced SCM and elucidates underlying mechanisms.
Zheng Liu, Qing Liu, Yujing Zhao, Junmei Xu, Yulong Cui   +4 more
doaj   +2 more sources

Autonomic Nervous System under Ketamine/xylazine and Pentobarbital Anaesthesia in a Wistar Rat Model: A Chronobiological View

Prague Medical Report, 2013
The aim of the present study was to determine the effect of ketamine/xylazine and pentobarbital anaesthesia on heart rate variability as a marker of autonomic nervous system activity. The experiments were performed in ketamine/xylazine (10 mg/kg/15 mg/kg)
Pavol Švorc, Jr., I. Bačová, P. Švorc, M. Bužga   +3 more
doaj   +2 more sources

Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex

Journal of Pharmacological Sciences, 2011
.: In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300
Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara   +9 more
doaj   +2 more sources

Interaction Between Different Extracts of Hypericum perforatum L. from Serbia and Pentobarbital, Diazepam and Paracetamol [PDF]

Molecules, 2014
Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs.
Aleksandar Rašković, Jelena Cvejić, Nebojša Stilinović, Svetlana Goločorbin-Kon, Saša Vukmirović, Neda Mimica-Dukić, Momir Mikov   +6 more
doaj   +2 more sources

The effect of different immobilization approaches on red-eared sliders [PDF]

Scientific Reports
The ethical issues surrounding sacrifice methods in animal experimentation have garnered increasing attention, making immobilization and sedation an integral part of the sacrifice process for experimental animals.
Xin Niu, Nuo Xu, Chengyu Cui, Shuangyan Wang, Zhenyang Yu, Haitao Shi, Meiling Hong, Li Ding   +7 more
doaj   +2 more sources

A Case of Pulmonary Edema Due to Pentobarbital Poisoning.

J Emerg Trauma Shock
Tashiro A, Tokutsu R, Tanaka N, Maekawa C, Nagatake Y, Kato M, Yanagawa Y.   +6 more
europepmc   +2 more sources

Effects of Anesthesia with Pentobarbital/Ketamine on Mitochondrial Permeability Transition Pore Opening and Ischemic Brain Damage [PDF]

Biomedicines
Background and Objective: The alteration of mitochondrial functions, especially the opening of the mitochondrial permeability transition pore (mPTP), has been proposed as a key mechanism in the development of lesions in cerebral ischemia, wherefore it is
Evelina Rekuviene, Laima Ivanoviene, Vilmante Borutaite, Ramune Morkuniene   +3 more
doaj   +2 more sources