Results 1 to 10 of about 178,601 (316)

Sevoflurane, as opposed to pentobarbital anesthesia, attenuates LPS-induced myocardial injury by up-regulating TAF1D [PDF]

Scientific Reports
Septic cardiomyopathy (SCM) is a prevalent and severe complication associated with sepsis. This study explores the effects of sevoflurane and pentobarbital on lipopolysaccharide (LPS) -induced SCM and elucidates underlying mechanisms.
Zheng Liu, Qing Liu, Yujing Zhao, Junmei Xu, Yulong Cui   +4 more
doaj   +2 more sources

Interaction Between Different Extracts of Hypericum perforatum L. from Serbia and Pentobarbital, Diazepam and Paracetamol [PDF]

Molecules, 2014
Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs.
Aleksandar Rašković, Jelena Cvejić, Nebojša Stilinović, Svetlana Goločorbin-Kon, Saša Vukmirović, Neda Mimica-Dukić, Momir Mikov   +6 more
doaj   +2 more sources

Stability of Sodium Pentobarbital 5w/v% Aqueous Solution During Short‐Term Chilled and Ambient‐Temperature Storage [PDF]

Veterinary Medicine and Science
The COVID‐19 pandemic made it difficult to obtain pharmaceutical‐grade injectable anaesthetics used in animal experiments in Japan. To address this problem, it is worth the effort to evaluate whether the use of non‐pharmaceutical‐grade sodium ...
Masakazu Dohi, Kayoko Ueda, Yoshinori Yamagiwa, Atsuko Yamashita, Yuji Sakamoto   +4 more
doaj   +2 more sources

The effect of different immobilization approaches on red-eared sliders [PDF]

Scientific Reports
The ethical issues surrounding sacrifice methods in animal experimentation have garnered increasing attention, making immobilization and sedation an integral part of the sacrifice process for experimental animals.
Xin Niu, Nuo Xu, Chengyu Cui, Shuangyan Wang, Zhenyang Yu, Haitao Shi, Meiling Hong, Li Ding   +7 more
doaj   +2 more sources

A Case of Pulmonary Edema Due to Pentobarbital Poisoning.

J Emerg Trauma Shock
Tashiro A, Tokutsu R, Tanaka N, Maekawa C, Nagatake Y, Kato M, Yanagawa Y.   +6 more
europepmc   +2 more sources

Effects of Anesthesia with Pentobarbital/Ketamine on Mitochondrial Permeability Transition Pore Opening and Ischemic Brain Damage [PDF]

Biomedicines
Background and Objective: The alteration of mitochondrial functions, especially the opening of the mitochondrial permeability transition pore (mPTP), has been proposed as a key mechanism in the development of lesions in cerebral ischemia, wherefore it is
Evelina Rekuviene, Laima Ivanoviene, Vilmante Borutaite, Ramune Morkuniene   +3 more
doaj   +2 more sources

Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report [PDF]

Journal of Neurocritical Care, 2023
Background Barbiturate poisoning is rare but potentially fatal. Case Report We reported a case of barbiturate poisoning in a 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning.
Amélie Giudicelli-Bailly, Chiara Della Badia, Marc Augsburger, Hervé Quintard, Raphaël Giraud, Pia De Stefano   +5 more
doaj   +1 more source

Thermal Response of Laboratory Rats (Rattus norvegicus) during the Application of Six Methods of Euthanasia Assessed by Infrared Thermography

Animals, 2023
Refinement is one of the principles aiming to promote welfare in research animals. The techniques used during an experimental protocol, including euthanasia selection, must prevent and minimize suffering.
Adriana Domínguez-Oliva, Ismael Hernández-Ávalos, Adriana Olmos-Hernández, Juan Villegas-Juache, Antonio Verduzco-Mendoza, Daniel Mota-Rojas   +5 more
doaj   +1 more source

Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric Procedural Sedation

Pharmaceutics, 2023
Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and therefore they must ...
Matthieu Lebrat, Yassine Bouattour, Coralie Gaudet, Mouloud Yessaad, Mireille Jouannet, Mathieu Wasiak, Imen Dhifallah, Eric Beyssac, Ghislain Garrait, Philip Chennell, Valérie Sautou   +10 more
doaj   +1 more source

Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors. [PDF]

PLoS ONE, 2016
BACKGROUND:Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that pentobarbital binds to some of the same sites where propofol and etomidate act.
Alexis M Ziemba, Stuart A Forman
doaj   +1 more source