Results 251 to 260 of about 178,601 (316)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, EarlyView.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source

Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension. [PDF]

PLoS One
Chen L, Chen J, Wan J, Shao M, Chen C, Zheng S, Zhang F, Yang J.   +7 more
europepmc   +1 more source

Splanchnic sympathetic nerve discharge and mean arterial pressure after heat lesion of rostral ventrolateral medulla in rats anesthetized with halothane or pentobarbital sodium.

, 1996
Yukihiko Hagiwara, Takao Kubo, Patrice G. Guyenet   +2 more
openalex   +1 more source

Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis

Small Science, EarlyView.
Current temporomandibular joint osteoarthritis (TMJOA) treatments lack progression control. MicroRNAs (miRNAs) offer therapeutic potential but face delivery hurdles. A novel nanodelivery system is developed using tetrahedral framework nucleic acids functionalized with miR‐143‐3p (tFNAs‐143). Tested in TMJOA models and inflammatory conditions, tFNAs‐143
Wenxiu Yuan, Maotuan Huang, Linxin Chen, Sihang Chen, Hanyu Lin, Nengwen Huang, Yifeng Xing, Chengchaozi Wang, Jie Lu, Min Fu, Linyu Xu, Jiang Chen   +11 more
wiley   +1 more source

Abdominal massage modulates gut microbiota and brain-gut peptides in insomnia model rats. [PDF]

Front Microbiol
Liu J, Aikebaier G, Lu X, Zhang X.
europepmc   +1 more source

Between a Constitutional Rock and a Procedural Hard Place: Placing Petitioners in an Eighth Amendment Battle of Persuasion [PDF]

, 2016
Nobriga, Kelley E.
core   +1 more source

Chondrocyte‐Targeted Nanoparticles Loaded with N‐Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance

Small Science, EarlyView.
Chondrocyte‐targeted CS‐NAC nanoparticles restore redox balance, inhibit ferroptosis, and protect cartilage under mechanical stress. This nanoplatform enhances joint retention, elevates GPX4 activity, and attenuates osteoarthritis progression, offering a promising disease‐modifying therapeutic strategy.
Shaoyi Wang, Fujian Zhang, Xiaocong Zhou, Jie Yang, Zhe Li, Songlin Li, Qunshan Lu, Houyi Sun, Peilai Liu   +8 more
wiley   +1 more source

Renal capsule patient-derived xenograft model for gastric cancer: establishment and MRI characterization. [PDF]

Front Immunol
Yin Z, Liu Q, Maswikiti EP, Wang Z, Bai Y, Xiang L, Wang Y, Ma B, Gao L, Shi J, Chen H.   +10 more
europepmc   +1 more source

GABAergic mechanisms of excitation and hypersynchrony in adult rat hippocampus [PDF]

, 2003
Uusisaari, Marylka
core