Results 251 to 260 of about 176,335 (333)

lncRNA LINC00958 Activates NOTCH3 by Competitively Inhibiting miR‐129‐2‐3p to Exacerbate the Malignant Biological Behaviors of Endometrial Cancer Cells

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Endometrial cancer (EC) is one of the most prevalent gynecologic malignancies, with increasing incidence worldwide. Recent studies have highlighted the critical roles of long noncoding RNAs (lncRNAs) in regulating tumor progression. This study investigated the oncogenic function of lncRNA LINC00958 in EC and its underlying mechanism involving ...
Xia Hong, Su‐Li He
wiley   +1 more source

Regulatory Effect and Mechanism of Tanshinone I on Cell Apoptosis in Steroid‐Induced Osteonecrosis of the Femoral Head

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SIONFH) is a debilitating orthopedic condition. This study investigated the mechanism of Tanshinone I (TsI) in SIONFH modulating apoptosis in SIONFH via the PI3K/AKT/mTOR pathway. A SIONFH rat model was treated with TsI and a PI3K activator. Bone mineral density (BMD), bone volume/total volume
Qing Su, Jia Chen
wiley   +1 more source

Glutamate Exacerbates Traumatic Brain Injury‐Induced Acute Lung Injury Through NMDAR/ROS/Ca2+ Signaling Pathway in Pulmonary Endothelial Cells

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Traumatic brain injury (TBI) causes a high level of blood glutamate, which triggers host defense by activating oxidative stress and inflammation response. However, the concrete mechanism underlying its exacerbating effects on acute lung injury (ALI) severity remains unknown.
Song Zhou   +2 more
wiley   +1 more source

Rosuvastatin Upregulates RCOR1 to Repress C10ORF10 Transcription and Alleviate Oxidative Stress and Plaque Formation in Atherosclerosis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rosuvastatin (RVS) is an HMG‐CoA reductase inhibitor with lipid‐lowering properties. This study aims to investigate the role of RVS in plaque formation in atherosclerosis (AS) and its functional mechanism. ApoE−/− mice were fed a high‐fat diet to generate a mouse model of AS.
Xin Fu   +5 more
wiley   +1 more source

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