Results 271 to 280 of about 178,601 (316)

Protective Role for Itaconate During Inhaled Allergen Challenge

Allergy, EarlyView.
Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers, Patricia P. Ogger, Christina Michalaki, Helen Stölting, Simone A. Walker, Anna Caldwell, John M. Halket, Kathryn Duvall, Atia Batool, Lisha Joshi, Helen O'Brien, Cormac McCarthy, Timothy Hinks, Gail M. Gauvreau, Paul M. O'Byrne, Clare M. Lloyd, Adam J. Byrne   +16 more
wiley   +1 more source

Hippocampal Transcriptome Analysis in a Mouse Model of Chronic Unpredictable Stress Insomnia. [PDF]

Biomedicines
Zhang S, Tong C, Cao N, Tian D, Du L, Xu Y, Wang W, Chen Z, Zhai S.   +8 more
europepmc   +1 more source

Medically Assisted Dying Practices: What Role for Clinical Ethicists?

Bioethics, EarlyView.
ABSTRACT Medically assisted dying (AD) practices have been legalized in several jurisdictions throughout the world over the last two decades. Because of this increased trend, more individuals now have access to a self‐chosen death. Despite its legalization and the diversity of frameworks governing AD, it remains fraught with ethical challenges. However,
Vanessa Finley‐Roy, Ralf J. Jox, Catherine Perron, Maire‐Eve Bouthillier   +3 more
wiley   +1 more source

<i>Panax notoginseng</i> Flower Extract Attenuates Pentylenetetrazole-Induced Epilepsy by Restoring Glutamate Homeostasis. [PDF]

Brain Sci
Zhao Y, Zhu F, Xie J, Wang Y, Matsabisa M, Tang M.   +5 more
europepmc   +1 more source

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source

Monitoring illicit pentobarbital availability in the United States: A National Drug Early Warning System briefing. [PDF]

Drug Alcohol Depend
Palamar JJ, Fitzgerald ND, Goldberger BA, Cottler LB.   +3 more
europepmc   +1 more source

Sedation Methods in Paediatric Auditory Electrophysiologic Testing: A Narrative Review. [PDF]

Audiol Res
Necula V, Domuta ME, Olariu R, Georgescu MG, Marchis IF, Stamate MC, Blebea CM, Dindelegan MG, Maniu AA, Pop SS.   +9 more
europepmc   +1 more source

Intravenous anesthetics have differential effects on human potassium channels. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Tao Y, Yao K, Wu J, Xu T, Lin J, Qin Y, Su D, Cai S, Yu W, Chen X.   +9 more
europepmc   +1 more source

ATAS-EMIT Activates the 5-HT/AC/cAMP Pathway to Ameliorate Insomnia in PCPA Insomniac Rats. [PDF]

Nat Sci Sleep
Liu L, Zuo Z, Wang Z, Li L, Fang Y, Guo C, Pan X, Xiao X.   +7 more
europepmc   +1 more source