Results 301 to 310 of about 173,723 (335)
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Antihistamine Potentiation of Pentobarbital Anesthesia*
Journal of the American Pharmaceutical Association (Scientific ed.), 1954The results of this investigation indicate that the common antihistamine drugs significantly prolong the sleeping time of pentobarbital anesthesia in the rat. The results of liver analyses indicate that the antihistamines do not seem to interfere with detoxication of pentobarbital. Evidence is presented to support the assumption that the antihistamines
Harold Lightstone, John W. Nelson
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Ethanol, Methamphetamine, Pentobarbital [PDF]
Archives of General Psychiatry, 1974 We find significant dose-response curves for social behaviors after single-dose administration of drugs in five adult male monkeys living in their "home" troop of about 30 animals. Ethanol (0 to 2 ml/kg, gavage) produced ataxia without motor slowing, regressive playful fighting typical of juveniles, and a substantial increase in the ratio of ...
A J Stynes +3 more
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The ciliospinal reflex in pentobarbital coma
Journal of Neurosurgery, 1999Object. This study was conducted to delineate the ciliospinal reflex (CSR), which is defined as pupillary dilation caused by a noxious stimulus to the face or head. The authors anecdotally observed that patients in a pentobarbital coma have a CSR that can mimic pathological conditions.
Jeffrey I. Frank +2 more
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Pentobarbital anesthesia in labor
American Journal of Obstetrics and Gynecology, 1967Abstract A routine method of balanced obstetric analgesia and anesthesia which can be administered safely by the labor room nurses and the attending physicians is discussed. Eleven thousand eight hundred and twenty patients received intravenous pentobarbital. More than 2,000 of the author's patients received this type of anesthesia. The result of his
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Sensitivity of AMPA receptors to pentobarbital
European Journal of Pharmacology: Molecular Pharmacology, 1994The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
Lu-Yang Wang +4 more
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Respiratory Effects of Quazepam and Pentobarbital
The Journal of Clinical Pharmacology, 1987Quazepam is a new benzodiazepine that may provide good hypnotic action with negligible effect on motor coordination or respiration. Sleep laboratory studies on human volunteers have shown quazepam 15 mg to be an effective hypnotic dose, with the 30‐mg dose being optimal.
Anne Murray +3 more
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Interaction of Doxapram and Pentobarbital in Mice
Pharmacology & Toxicology, 1991We found a statistically significant increase in duration of pentobarbital‐induced narcosis in doxapram‐treated mice. The influence of doxapram (a respiratory stimulant) pretreatment on pentobarbital metabolism in mice was assessed by measurements of sleeping times, hypothermia, LD50 values, hepatic microsomal metabolism and relative plasma and brain ...
Masayasu Ozaki +4 more
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Diazepam and pentobarbital dependence in the rat
Life Sciences, 1982Diazepam (100-133 mg/kg/day), administered chronically through a gastric fistula, and pentobarbital (ca 692 mg/kg/day), administered chronically in food, were studied for their dependence producing properties in Sprague-Dawley female rats. The diazepam abstinence syndrome was apparent 10 to 20 hours after withdrawal, persisted for over 60 hours and ...
W.R. Martin, L.F. McNicholas, S. Cherian
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Neuropharmacology, 1979
Abstract Functional (CNS) tolerance to the hypnotic effect of barbiturates was determined in vivo by comparing the brain barbiturate level at awakening from a test dose in control rats and rats chronically treated with barbiturate. Approximately two-fold CNS tolerance to barbital was achieved by giving rats increasing concentrations of barbital in ...
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Abstract Functional (CNS) tolerance to the hypnotic effect of barbiturates was determined in vivo by comparing the brain barbiturate level at awakening from a test dose in control rats and rats chronically treated with barbiturate. Approximately two-fold CNS tolerance to barbital was achieved by giving rats increasing concentrations of barbital in ...
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Pharmacokinetics of pentobarbital in the dog.
The Journal of Pharmacology and Experimental Therapeutics, 1983The pharmacokinetics of pentobarbital were studied after i.v. administration of a 30-mg/kg dose to five dogs. Pentobarbital plasma concentrations were measured with a new gas chromatographic method, utilizing on-column methylation of pentobarbital and as a butabarbital internal standard.
M C, Frederiksen +3 more
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