Results 311 to 320 of about 173,723 (335)
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Pharmacology Biochemistry and Behavior, 1982
Rats were given five separate pairings (sequential IP injections) of pentobarbital and lithium chloride, both hypothermia-inducing agents. When the animals were subsequently tested with a single injection of pentobarbital alone, they exhibited an attenuated hypothermia relative to controls that had either (a) received pentobarbital-LiCl pairings spaced
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Rats were given five separate pairings (sequential IP injections) of pentobarbital and lithium chloride, both hypothermia-inducing agents. When the animals were subsequently tested with a single injection of pentobarbital alone, they exhibited an attenuated hypothermia relative to controls that had either (a) received pentobarbital-LiCl pairings spaced
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Interaction of cannabinoids with pentobarbital in rats
Toxicology and Applied Pharmacology, 1974The effect of cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), Δ8-tetrahydrocannabinol (Δ8-THC), and Δ9-tetrahydrocannabinol (Δ9-THC) on the in vivo metabolism of [14C]pentobarbital (14C-P) was investigated in rats. The cannabinoids were administered ip (20 mg/kg) 30 min prior to either oral or iv treatment with 14C-P.
Blake B. Coldwell +3 more
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Effect of pentobarbital on the disposition of alprenolol
Clinical Pharmacology & Therapeutics, 1977Alprenolol was administered orally and intravenously to 5 healthy subjects before and after IO to 14 daily doses of 0.1 gm pentobarbital. The area under the plasma concentration time curve after an oral 200‐mg dose decreased from 706 ± 277 to 154 ± 48 ng/ml .
Gunnar Alván +3 more
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Pentobarbital sodium anesthesia in the dog
American Journal of Physiology-Legacy Content, 1965Studies have been done in the dog to determine some of the circulatory effects of anesthetic amounts of pentobarbital sodium. The results indicate that a) except for the initial transient hypotension that occurs on injection of the anesthetic, pentobarbital sodium has little influence on the mean arterial blood pressure of the normotensive dog; b ...
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Pentobarbital actions on a leech neurone
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1977Abstract 1. Pentobarbital and secobarbital caused changes in resting properties of leech neurones attributable to reduced potassium conductance, but several other barbiturates had no effect. 2. All barbiturates tested prolonged the action potentials of the same cells. 3. For pentobarbital both actions were much more evident at pH 6.8 than at 8.8.
Anna L. Kleinhaus, James W. Prichard
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Biological Activity of Pentobarbital Metabolites
Journal of Pharmaceutical Sciences, 1973Abstract The (1′ S ,3′ R )-, (1′ S ,3′ S )-, (1′ R ,3′ S )-, and (1′ R ,3′ S )-5-ethyl-5-(3′-hydroxy-1′-methylbutyl)barbituric acid metabolites of pentobarbital are relatively inactive and, therefore, cannot account for the differences in potency found between R (+)- and S (–)-pentobarbital.
F. I. Carroll +2 more
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Oral pentobarbital intoxication in a bitch
Journal of the American Veterinary Medical Association, 1986Pentobarbital intoxication in a 5-year-old female Samoyed was confirmed by the finding of a high concentration of the drug in serum. The dog apparently had consumed one of her pups, which had been euthanatized the day before with a 26% sodium pentobarbital solution. She was admitted in a condition consistent with light general anesthesia.
V, Fucci +3 more
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Placental Transfer of Pentobarbital in the Rat
Journal of Pharmaceutical Sciences, 1970The placental transfer of pentobarbital and/or metabolites was determined in rats using 14C-labeled pentobarbital. The level of pentobarbital and/or metabolites in fetal blood was greatly influenced by the circulating level of pentobarbital and/or metabolites in the mother.
David P.S. Mork +2 more
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Behavioral and Neural Biology, 1983
Rats with conditioned aversions to NaCl water were exposed to either an injection of pentobarbital (Pent) followed 30 min later by an injection of lithium chloride (LiCl) on four separate occasions or to injections of LiCl alone, Pent alone, or LiCl followed by Pent. These injections were followed by pairings of NaCl consumption with injections of Pent.
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Rats with conditioned aversions to NaCl water were exposed to either an injection of pentobarbital (Pent) followed 30 min later by an injection of lithium chloride (LiCl) on four separate occasions or to injections of LiCl alone, Pent alone, or LiCl followed by Pent. These injections were followed by pairings of NaCl consumption with injections of Pent.
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