Results 71 to 80 of about 165,661 (337)
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Scientific Reports, 2023 Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. The SCA-to-resuscitation interval is a key determinant of patient outcomes, highlighting the clinical need for reliable and timely detection of SCA. Near-infrared spectroscopy (NIRS),
Katharina Raschdorf +11 more
doaj +1 more source
Alterations in protein P53 expression during the development of pressure overload-induced left ventricular hypertrophy in rats [PDF]
, 2008 The relation between myocardial structural and functional changes and p53 proteins during the development of left ventricular hypertrophy (LVH) has not yet been reported.
Stoyanova, V., Zhelev, Nikolai
core +4 more sources
Advanced Science, EarlyView.The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu +13 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 491-501, December 2022., 2022 Flight and freezing are two vital defensive behaviors in the process of avoiding natural enemies in mice. We investigated the neural activity in dPAG nuclei of mice under two defensive behaviors, and found different coding features between flight and freezing behaviors. Abstract Background Flight and freezing are two vital defensive behaviors that mice
Denghui Liu +5 more
wiley +1 more source
In vivo neurological assessment of sedative hypnotic effect of Coriandrum sativum L. seeds in mice. [PDF]
, 2015 Ethnopharmacological relevance: seeds of Coriandrum sativum L. have been used in the traditional medicine to relieve stress and other neurological disease conditions.
Abdulrahman M Alshahrani
core +1 more source
Latent Hypersensitivity to Pentobarbital in the Rat.
Experimental Biology and Medicine, 1966 SummaryRats receiving a fixed anesthetic dose of pentobarbital developed hypersensitivity to the drug 28 days following tolerance induction. This delayed increase in sleeping time was non-significant in the male, but significant in the female animal (P = 0.05).
openaire +3 more sources
Advanced Science, EarlyView.A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen +8 more
wiley +1 more source
Molecules, 2014 Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs.
Aleksandar Rašković +6 more
doaj +1 more source
EFFECT OF PANCREOZYMIN ON RAT PANCREATIC ENZYME BIOSYNTHESIS [PDF]
, 1971 Pancreatic enzyme secretion in rats anesthesized by pentobarbital was stimulated by intravenous perfusion of the hormone pancreozymin, as indicated by a decreased amylase level in the pancreas and by specific, fine structural changes observed in an ...
Cailla-Deckmyn, H. +2 more
core +3 more sources