Results 71 to 80 of about 52,516 (291)
Advanced Science, EarlyView.PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou +7 more
wiley +1 more source
Latent Hypersensitivity to Pentobarbital in the Rat.
Experimental Biology and Medicine, 1966 SummaryRats receiving a fixed anesthetic dose of pentobarbital developed hypersensitivity to the drug 28 days following tolerance induction. This delayed increase in sleeping time was non-significant in the male, but significant in the female animal (P = 0.05).
openaire +3 more sources
Bucklew v. Precythe: The Power of Assumptions and Lethal Injection [PDF]
, 2019 Once again, the Supreme Court of the United States has an opportunity to determine the extent to which death-row inmates can bring as-applied challenges to the states’ method of execution and prevent possible botched executions. In Bucklew v.
Gomez, Renata
core +1 more source
Evidence for engraftment of human bone marrow cells in non-lethally irradiated baboons [PDF]
, 1997 Background. Prior to organ harvesting, an attempt was made to modulate the donor's immune responses against prospective xenogeneic recipients by infusion of 'recipient-type' bone marrow. Methods.
Fontes, P +7 more
core +1 more source
Advanced Science, EarlyView.Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu +12 more
wiley +1 more source
Too Sick to Be Executed: Shocking Punishment and the Brain [PDF]
, 2016 Capital punishment, to be lawfully delivered, must occur without needless cruelty. Cruelty, defined in the setting of punishment, will naturally evolve with the maturation of civil society.
Zivot, Joel
core +1 more source
Improvement of Impaired Memory in Mice by Taurine
Neural Plasticity, 2000 Taurine was extracted from Pegasus later-narius Cuvier to study its effects on learning and memory in mice. Mice were treated with different doses of taurine (10 mg/kg, 20 mg/kg, 40 mg/kg).
Bhupinder P. S. Vohra, Xiang Hui
doaj +1 more source
Advanced Science, EarlyView.Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li +8 more
wiley +1 more source
In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach [PDF]
, 2019 The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled.
Croubels, Siska +3 more
core +1 more source
Molecules, 2014 Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs.
Aleksandar Rašković +6 more
doaj +1 more source