Results 71 to 80 of about 173,723 (335)
LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.This study investigates the mechanism of succinate dehydrogenase (SDH)‐mediated succinate oxidation in microglia extracellular traps (MiETs) formation and neuronal injury after cerebra I/R injury. Dimethyl malonate (DMM), a competitive SDH inhibitor, could reduce MiETosis by inhibiting succinate oxidation and mtROS production during reperfusion ...
Lili Zhao +21 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 The second-generation histamine-H1-receptor antagonists, such as epinastine and cetirizine, are used as non-sedating antihistamines for treating allergic symptoms due to their poor ability to penetrate blood-brain barrier.
Junzo Kamei +4 more
doaj +1 more source
Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues [PDF]
, 2007 Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia.
Keigo Endo +6 more
core +1 more source
Advanced Science, EarlyView.CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen +10 more
wiley +1 more source
Stability-Indicating Assay for the Determination of Pentobarbital Sodium in Liquid Formulations
International Journal of Analytical Chemistry, 2015 A stability-indicating assay by reversed-phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of pentobarbital sodium in oral formulations: a drug used for infant sedation in computed tomography (CT) or ...
Myriam Ajemni +6 more
doaj +1 more source
Scientific Reports, 2023 Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. The SCA-to-resuscitation interval is a key determinant of patient outcomes, highlighting the clinical need for reliable and timely detection of SCA. Near-infrared spectroscopy (NIRS),
Katharina Raschdorf +11 more
doaj +1 more source
Advanced Science, EarlyView.The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu +20 more
wiley +1 more source
JEM ReportsBackground: Pentobarbital is a short-acting barbiturate that can cause life-threatening central nervous system, respiratory, and cardiovascular depression if massively overdosed.
Sohma Miyamoto +4 more
doaj +1 more source