TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway [PDF]
Scientific Reports, 2015 AbstractPrevious study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. However, it remains unexplored if TIGAR plays an important role in DNA damage and repair. This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and ...
Hong-Pei Yu +7 more
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A Flux Model of Glycolysis and the Oxidative Pentosephosphate Pathway in Developing Brassica napus Embryos [PDF]
Journal of Biological Chemistry, 2003 Developing oilseeds synthesize large quantities of triacylglycerol from sucrose and hexose. To understand the fluxes involved in this conversion, a quantitative metabolic flux model was developed and tested for the reaction network of glycolysis and the oxidative pentose phosphate pathway (OPPP).
Jorg, Schwender +2 more
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Insights into the autotrophic CO2 fixation pathway of the archaeon Ignicoccus hospitalis: comprehensive analysis of the central carbon metabolism. [PDF]
J Bacteriol, 2007 Ignicoccus hospitalis is an autotrophic hyperthermophilic archaeon that serves as a host for another parasitic/symbiotic archaeon, Nanoarchaeum equitans. In this study, the biosynthetic pathways of I.
Jahn U +4 more
europepmc +3 more sources
The formation and breakdown of pentosephosphates by liver fractions [PDF]
, 1952 Gertrude E. Glock
core +3 more sources
Chemie Ingenieur Technik, Volume 94, Issue 6, Page 864-872, June 2022., 2022 Eine automatisierte Anlage zur Schnellfiltration ermöglicht die Bestimmung intrazellulärer Metaboliten bei höheren Biomassekonzentrationen für Stoffwechseluntersuchungen, beispielhaft dargestellt anhand der Untersuchung einer Modifikation der Aspartokinase in Corynebacterium glutamicum. Zudem weist sie den Weg zu einer Filtration im Sekundenbereich für
Enrico Hans, An‐Ping Zeng
wiley +1 more source
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice [PDF]
, 2021 Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular origins of these chronic conditions remain elusive.
Akhtar, A. +6 more
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 The cause of Alzheimer’s disease, the most common type of dementia today, is still unclear, and in current research, there are no drugs that work relatively well. Therefore, the study for new drugs to treat Alzheimer’s disease is an urgent research need. Research on the improvement of Alzheimer’s disease with extracts of Xanthoceras sorbifolia has been
Rui Han +8 more
wiley +1 more source
Is serum biotinidase enzyme activity a potential marker of perturbed glucose and lipid metabolism?
JIMD Reports, Volume 57, Issue 1, Page 58-66, January 2021., 2021 Abstract Glycogen storage diseases (GSDs) belong to the group of inborn errors of carbohydrate metabolism. Hepatic GSDs predominantly involve the liver and most present with hepatomegaly. Biochemically they show known disturbances in glucose and fatty acids metabolism, namely fasting hypoglycaemia and increased triglycerides.
Patrick Forny +3 more
wiley +1 more source
Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence. [PDF]
, 2010 International audienceBACKGROUND: Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C.
Andreesen, Jan +13 more
core +5 more sources
A multi-level study of recombinant Pichia pastoris in different oxygen conditions [PDF]
, 2010 Background: Yeasts are attractive expression platforms for many recombinant proteins, and there is evidence for an important interrelation between the protein secretion machinery and environmental stresses.
Albiol i Sala, Joan +10 more
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