Results 1 to 10 of about 925 (73)

Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases

Communications Chemistry
Glycosylated derivatives of natural product polyphenols display a spectrum of biological activities, rendering them critical for both nutritional and pharmacological applications.
Tuo Li, Annika J. E. Borg, Leo Krammer, Hansjörg Weber, Rolf Breinbauer, Bernd Nidetzky   +5 more
doaj   +2 more sources

One-Pot Hetero-Di-C-Glycosylation of the Natural Polyphenol Phloretin by a Single C-Glycosyltransferase With Broad Sugar Substrate Specificity. [PDF]

Biotechnol Bioeng
Here, an efficient system for synthesizing high‐value polyphenol hetero‐di‐C‐glycosides with two distinct C‐glycosyl residues was established using a two‐step glycosylation catalyzed by C‐glycosyltransferase in one pot. The desired C‐β‐galactosyl‐C‐β‐glucosyl and C‐β‐glucosyl‐C‐β‐xylosyl phloretin were obtained at concentrations of 0.6 and 6 g/L ...
Li T, Borg AJE, Krammer L, Breinbauer R, Nidetzky B.   +4 more
europepmc   +2 more sources

Measuring catalytic mechanism similarity - a new approach to study enzyme function and evolution. [PDF]

FEBS J
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Ribeiro AJM, Riziotis IG, Borkakoti N, Fernandes PA, Ramos MJ, Thornton JM.   +5 more
europepmc   +2 more sources

Copy Number Variations Analysis Identifies QPRT as a Candidate Gene Associated With Susceptibility for Solitary Functioning Kidney

Frontiers in Genetics, 2021
BackgroundThe lack of understanding of molecular pathologies of the solitary functioning kidney makes improving and strengthening the continuity of care between pediatric and adult nephrological patients difficult.
Xiao Y. Zhou, Hao Y. Zheng, Li Han, Yan Wang, Li Zhang, Xiao M. Shu, Mu L. Zhang, Guan N. Liu, Lian S. Ding   +8 more
doaj   +1 more source

The biosynthesis, degradation, and function of cell wall β‐xylosylated xyloglucan mirrors that of arabinoxyloglucan

New Phytologist, Volume 240, Issue 6, Page 2353-2371, December 2023., 2023
Summary Xyloglucan is an abundant polysaccharide in many primary cell walls and in the human diet. Decoration of its α‐xylosyl sidechains with further sugars is critical for plant growth, even though the sugars themselves vary considerably between species. Plants in the Ericales order – prevalent in human diets – exhibit β1,2‐linked xylosyl decorations.
Louis F. L. Wilson, Stefanie Neun, Li Yu, Theodora Tryfona, Katherine Stott, Florian Hollfelder, Paul Dupree   +6 more
wiley   +1 more source

Exploring the Unique N-Glycome of the Opportunistic Human Pathogen Acanthamoeba*

Journal of Biological Chemistry, 2012
Background: Acanthamoeba is a facultative parasite of humans capable of causing keratitis or encephalitis. Results: Novel N-glycan modifications, including core mannosylated fucose, mannose 6-phosphate, and multiple pentose residues, were observed ...
B. Schiller, G. Makrypidi, E. Razzazi-Fazeli, K. Paschinger, J. Walochnik, I. Wilson   +5 more
semanticscholar   +1 more source

Identification and role of differentially expressed genes/proteins between pulmonary tuberculosis patients and controls across lung tissues and blood samples

Immunity, Inflammation and Disease, Volume 12, Issue 7, July 2024.
Eight common differentially expressed genes/proteins(DEGs/DEPs) of lung tissues and blood samples were identified, including TYMP, LAP3, ADGRL2, SIL1, LMO7, SULF1, ANXA3 and PACSIN3. They may be associated with the inflammation of tuberculosis patients.
Qifeng Li, Kuerbanjiang Maierheba
wiley   +1 more source

Mild limb girdle muscular dystrophy R9 phenotype caused by novel compound heterozygous FKRP gene mutation. [PDF]

Acta Myol, 2023
Belhassen I, Menassa R, Sakka S, Michel-Calemard L, Streichenberger N, Ayed DB, Bouattour N, Dammak M, Mhiri C.   +8 more
europepmc   +1 more source

Biotechnological and Biomedical Applications of Enzymes Involved in the Synthesis of Nucleosides and Nucleotides. [PDF]

Biomolecules, 2021
Fernández-Lucas J.
europepmc   +1 more source

Optical Genome Mapping: Integrating Structural Variations for Precise Homologous Recombination Deficiency Score Calculation. [PDF]

Genes (Basel), 2023
Sahajpal NS, Mondal AK, Vashisht A, Singh H, Pang AWC, Saul D, Nivin O, Hilton B, DuPont BR, Kota V, Savage NM, Hastie AR, Chaubey A, Kolhe R.   +13 more
europepmc   +1 more source