Results 1 to 10 of about 19,352 (114)

Pentoxifylline in Dogs With Osteoarthritis: Comparative Treatment and Efficacy Analysis With Meloxicam. [PDF]

Vet Med Sci
12 dogs with bilateral knee osteoarthritis were treated with either meloxicam or pentoxifylline over 60 days. Pentoxifylline showed superior reductions in inflammatory markers (CRP, IL‐1β, IL‐6, TNF‐α) and improved joint biochemical parameters, particularly hyaluronic acid levels and cartilage oligomeric matrix protein (COMP).
Parlak K, Zamirbekova Erdogan N, Parlak TM, Uzunlu EO, Dik B.   +4 more
europepmc   +2 more sources

Colo-Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: New Molecular Approach. [PDF]

Pharmacol Res Perspect
ABSTRACT Multiple signaling pathways have been implicated in the pathogenesis of ulcerative colitis (UC), including Sphingosine Kinase 1 (SPHK)/Sphingosine‐1‐Phosphate (S1P), AMP‐activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/NLR family pyrin domain‐containing 3 (NLRP3), zonula occludens‐1 (ZO‐1), and signal transducer and ...
Alherz FA, Abdallah MS, Mosalam EM, Bahaa MM, Elmasry TA, El-Gammal MA, Negm WA, Elberri A, Elshorbagi N, Abo Mansour HE, Hamouda AO, Salahuddin MM, Yasser M, Eldesoqui M, Alrubia S, Alsegiani AS, El-Khateeb E, ElMahdy MK, Wahsh E.   +18 more
europepmc   +2 more sources

Effective Treatment of Livedoid Vasculopathy With Oral Tofacitinib. [PDF]

Clin Case Rep
ABSTRACT We present a woman with severe refractory livedoid vasculopathy who was successfully treated with tofacitinib (5 mg twice a day). The ulcers gradually healed over a period of 2–3 months without experiencing any adverse events over a 1‐year follow‐up period.
Mansouri P, Mozafari N.
europepmc   +2 more sources

Overcoming Intrapulmonary Shunting: A Case Report of Hepatopulmonary Syndrome Post-Liver Transplantation Treated With Inhaled Treprostinil. [PDF]

Respirol Case Rep
Hepatopulmonary syndrome (HPS) poses a significant challenge in liver transplant recipients, often resulting in persistent hypoxaemia postoperatively. This case highlights the persistence of hypoxaemia post‐liver transplantation in HPS patients and underscores the potential role of inhaled Treprostinil as a novel therapeutic approach to address this ...
Fanous J, McNierney D, Abdalla A, Azar J.   +3 more
europepmc   +2 more sources

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]

, 2015
A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
core   +2 more sources

Silence of the limbs: pharmacological symptomatic treatment of intermittent claudication [PDF]

, 2010
Several oral "vasoactive" drugs claim to increase walking capacity in patients with intermittent claudication (IC). Naftidrofuryl, cilostazol, buflomedil, and pentoxifylline are the most studied molecules.
De Backer, Gui, De Backer, Tine, De Buyzere, Marc, Van Bortel, Lucas, Vander Stichele, Robert   +4 more
core   +1 more source

Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. [PDF]

, 2012
We describe the course and likely pathophysiology of impending anterior ischemic optic neuropathy (AION) and retinal vein occlusion in a 56-year-old man with polycythemia vera managed with interferon alpha for 2 years.
Hirsch, Louis K, Rue, Kelly S, Sadun, Alfredo A   +2 more
core   +1 more source

Vasodilatory effect of pentoxifylline in isolated equine digital veins [PDF]

, 2012
The direct vasodilatory action of pentoxifylline (1-(5-oxohexyl)-3,7-dimethylxanthine) and its signalling pathway was evaluated in equine digital veins.
C. Thorin, G. Chatagnon, J. Noireaud, J.C. Desfontis, M. Gogny, M.Y. Mallem, N. Kabbesh   +6 more
core   +4 more sources

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources