Results 151 to 160 of about 13,383,705 (258)

The Hidden Epidemic: Epidemiology of Acute Infections in People Who Inject Drugs in Fiji. [PDF]

Drug Alcohol Rev
Naidu M, Chandra Y.
europepmc   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Projected Health and Economic Outcomes in People Who Inject Drugs in the United States, 2025-2034: A Modeling Study. [PDF]

Open Forum Infect Dis
Chiosi JJ, Giardina J, Wakeman SE, Freedberg KA, Chhatwal J, Ciaranello AL.   +5 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

An Exploratory Intersectional Analysis of Lifetime Syphilis Prevalence Among People Who Inject Drugs in Montreal, Canada. [PDF]

Sex Transm Dis
Harney BL, Bruneau J, Martel-Laferrière V, Larney S.   +3 more
europepmc   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Characteristics of People Who Inject Drugs Approached for Injection Assistance in Rural Kentucky. [PDF]

J Stud Alcohol Drugs
Young A, Hockensmith R, Tolbert PT, Westneat S, Vickerman P, Stone J, Surratt HL, Fujimoto K, Knudsen HK, Vickers-Smith R, Thompson KL, Fanucchi L, Kollitz J, Havens JR, Livingston MD.   +14 more
europepmc   +1 more source

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

Gender and Drug Use Discrimination Among People Who Inject Drugs: An Intersectional Approach Using the COSINUS Cohort

Ilhame Anwar,1 Aissatou Faye,1 Jessica Pereira Gonçalves,1 Laélia Briand Madrid,1 Gwenaëlle Maradan,2 Laurence Lalanne,3,4,* Marie Jauffret-Roustide,5– 7,* Marc Auriacombe,8– 10,* Perrine Roux1 1Aix Marseille Univ, Inserm, IRD, SESSTIM ...
Anwar I, Roux P, Auriacombe M, Briand Madrid L, Jauffret-Roustide M, Maradan G, Faye A, Lalanne L, Pereira Gonçalves J   +8 more
core  

Profile of risk factors for people who inject drugs among a sample at high risk of HIV/AIDS in Kigali, Rwanda. [PDF]

Adv Drug Alcohol Res
Habimana S, Lister Z, Biracyaza E, Kagaba A, Ndagijimana A, Jansen S, Rutembesa E, Montgomery S.   +7 more
europepmc   +1 more source