Results 161 to 170 of about 13,383,705 (258)

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

Advanced Science, EarlyView.
A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng, Yi Zhu, Xinrui Li, Sunxian Dai, Xiangyuan Ma, Hongwei Lu, Zhongling Wang, Benqing Zhou   +7 more
wiley   +1 more source

Difficulty accessing drug treatment among a national sample of people who regularly inject drugs, Australia, 2023.

The aim of this bulletin is to examine whether people who inject drugs experience difficulty accessing treatment and if so, what services they have difficulty accessing and the barriers to access among a sample of people in Australia who regularly inject
Chandrasena, Udesha, Sutherland, Rachel, Peacock, Amy   +2 more
core  

Prevalence of Wounds and Association With Xylazine Using Respondent-driven Sampling Among People Who Inject Drugs in Baltimore, Maryland. [PDF]

J Addict Med
Ponce AN, German D, McMahon MMA, Ashburn K, McFall A, Genberg BL.   +5 more
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

The pathway to establishing and implementing opioid agonist therapy (OAT) for people who inject drugs in Nairobi, Kenya. [PDF]

Front Public Health
Koech E, Welsh C, Karanja M, Boit J, Wangusi R, Awuor P, Munyao O, Masai T, Wafula S, Ngunu C, Kenyatta O, Mutisya I, Mwangi J, Gichuhi B, Lyn A, Stafford K, Lascko T, Ndichu G, Ng'eno C.   +18 more
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Bacterial Carriage and Invasive Infections Among People Who Inject Drugs: Clinical and Molecular Epidemiology in an Australian Prospective Cohort. [PDF]

Open Forum Infect Dis
Attwood LO, O'Keefe D, Wisniewski JA, Doan NQ, Petrovic B, Beiers M, Vujovic O, Curtis SJ, Higgs P, Hawkey J, Doyle JS, Peel TN, Peleg AY, Dietze P, Stewardson AJ.   +14 more
europepmc   +1 more source

A Magnetic‐Driven Self‐Rotation‐Stabilized Miniature Swimming Robot

Advanced Science, EarlyView.
Inspired by the stable rotational descent of seeds in nature, this study designs a magnetic‐driven self‐rotation‐stabilized miniature swimming robot (MSMSR). Based on a resonance‐driven strategy, the robot exhibits high swimming performance, offering enhanced directional swimming and improved resistance to water flow disturbances compared to existing ...
Fujun Wang, Chuhan Zhang, Hao Zhang, Yanling Tian, Cunman Liang   +4 more
wiley   +1 more source

Tricuspid valve endocarditis in people who inject drugs: strategies to reduce mortality and recurrent infection. [PDF]

Ann Cardiothorac Surg
de Waha S, Noack T, Kister T, Desch S, Marín-Cuartas M, Kiefer P, Borger MA.   +6 more
europepmc   +1 more source