Results 161 to 170 of about 26,526,867 (295)

Health Harms Associated With Forced Displacements Among People Who Use Drugs in San Francisco, California. [PDF]

Subst Use Addctn J
Chung EO, Megerian CE, Suen LW, Wenger LD, Ray B, Lambdin BH, Kral AH.   +6 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Surveillance, violence, and assistance: Distinct typologies of police contact and prospective health outcomes among people who use drugs. [PDF]

Soc Sci Med
Rouhani S, Khezri M, Schneider KE, Tomko CA, Sisson LN, Martin EM, Nestadt DF, Sherman SG.   +7 more
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Estimating the population size of people who inject drugs in Canada, 2021.

BACKGROUND: People who inject drugs are disproportionately affected by HIV and hepatitis C infections. Estimating the size and distribution of this population is essential in monitoring infectious diseases rates and progress towards elimination ...
Williams, Anson, Yang, Qiuying, Cox, Joseph, Sorge, Justin, Smoke, Ashley, Popovic, Nashira, Périnet, Simone, Bonn, Matthew   +7 more
core   +1 more source

The symbolic power of decriminalization and recriminalization in shaping stigma toward people who use drugs in British Columbia. [PDF]

BMC Public Health
Ali F, Mende-Gibson J, Russell C, Bardwell G, Budau J, Ivsins A, Mitra S, Rehm J.   +7 more
europepmc   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Encampment sweeps and persistent homelessness among unhoused people who use drugs in Vancouver, Canada: A prospective cohort study. [PDF]

PLoS Med
Hayashi K, Sayre EC, McDermid J, Marsh S, Shane C, Milloy MS, P.O.W.E.R., Kerr T.   +7 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Examining Increased Ritalin and Adderall Use Among Low-Income People Who Use Drugs: Mixed Methods Study. [PDF]

JMIR Form Res
Aronson ID, Quiles R, Cramer A, Fong C, Bennett AS.   +4 more
europepmc   +1 more source