Results 151 to 160 of about 60,176 (288)

Salivary Pepsin Test in the Diagnosis of Laryngopharyngeal Reflux Disease: Reality or Fallacy? [PDF]

World J Otorhinolaryngol Head Neck Surg
Li JR, Allen JE, Lechien JR.
europepmc   +1 more source

Cost–Utility Analysis of Wireless Versus Catheter‐Based Oesophageal pH Monitoring in the Pre‐Operative Assessment of Anti‐Reflux Surgery: A Decision‐Analytic Model

ANZ Journal of Surgery, EarlyView.
Oesophageal pH monitoring is an important component of preoperative workup for anti‐reflux surgery. This single‐centre cost–utility analysis found that wireless pH monitoring was associated with lower expected healthcare costs and higher QALYs, supporting it as a potentially cost‐effective alternative.
Du H. Phan, Naomi Moy, Iain G. Thomson, Adam J. Frankel   +3 more
wiley   +1 more source

Effects of Alcalase and Pepsin Hydrolysis on Gel Forming Behavior and Technological Properties of Porcine Skin Gelatin. [PDF]

Gels
Wi CH, Hwang J, Son WY, Kim HW.
europepmc   +1 more source

Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat‐Dose Administration for up to 14 Days

Alimentary Pharmacology &Therapeutics, EarlyView.
In this Phase 1 study, linaprazan glurate (LG) demonstrated rapid onset of intragastric acid suppression, achieving a pH > 4 within 10 to 60 min, and maintained pH control, with a 24‐h pH > 4 holding time ratio above 95% at 50 mg and 75 mg twice‐daily doses. AUC and Cmax of linaprazan, the main metabolite of LG, increased in proportion to LG dose.
Kajsa Larsson, Kjell Andersson, Gunilla Huledal, Jouni Junnila, Kristofer Katkits Nilsson, Elham Yektaei, Matjaž Fležar, Peter Unge   +7 more
wiley   +1 more source

Algal and Cyanobacterial Hydrolysates as Serum-Reducing Supplements Across Mammalian, Avian and Fish Cells with Identification of Bioactive Chromopeptides. [PDF]

Foods
Sibinčić-Georgieva N, Aleksić L, Grozdanić Stanisavljević N, Tubić L, Tanasković B, Gligorijević N, Stojadinović M, Minić S.   +7 more
europepmc   +1 more source

Comorbid conditions after allogeneic haematopoietic stem cell transplantation in young adults in Germany—A prospective, multicentre trial

British Journal of Haematology, EarlyView.
Summary Young adults (YA) are particularly affected by comorbid conditions following allogeneic haematopoietic stem cell transplantation (alloHSCT), as they have to live with them for many years. This is the first multicentre prospective study investigating sequelae after alloHSCT in YA in Germany. In total, 107 patients who survived relapse‐free until
Pauline Rocke, Lena Tandetzky, Daniel Wolff, Katharina Egger‐Heidrich, Daniela Heidenreich, Kerstin Schaefer‐Eckart, Eva Wagner‐Drouet, Jochen J. Frietsch, Andreas Hochhaus, Inken Hilgendorf   +9 more
wiley   +1 more source

Caution: fundamental data quality issues underlying intelligent prediction of enzyme optimal pH. [PDF]

Brief Bioinform
Zhou P, Fang X.
europepmc   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Cifuentes P, Garriga A, Fontaine F, Zamora I.   +3 more
europepmc   +2 more sources

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Protease-assisted microencapsulation of carvacrol in pea protein systems for enhanced and durable antibiofilm activity. [PDF]

Curr Res Food Sci
Ji J, Chihib NE, Agusti G, Dumas E, Gharsallaoui A.   +4 more
europepmc   +1 more source