Results 151 to 160 of about 151,608 (341)

Sarcopenia ‘made simple’ and outcomes from emergency laparotomy

open access: yesANZ Journal of Surgery, Volume 92, Issue 12, Page 3198-3203, December 2022., 2022
CT‐assessed ratio of L3 vertebral body cross‐sectional area to total psoas muscle cross‐sectional area (L3:PM) is a simple yet significant predictor of 30‐, 90‐ and 365‐day mortality in emergency laparotomy patients. This study is the first to describe the association in an Australian population.
Yan Joyce Ming   +4 more
wiley   +1 more source

Peptic Ulcer Diagnosis and Treatment [PDF]

open access: bronze, 1957
Clifford J. Barborka, E. Clinton Texter
openalex   +1 more source

40 years after the discovery of Helicobacter Pylori: Performing optimized “subtraction” for clinical eradication

open access: yesiMetaOmics, EarlyView.
It has been 40 years since the first discovery of the important human pathogen, Helicobacter pylori (H. pylori). Eradication of the infection continues to pose significant challenges in part because of the global increase in antibiotic resistance. Generally, the “addition” strategy has failed to deliver the desired results for more than a short period ...
Yi Hu   +14 more
wiley   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz   +12 more
wiley   +1 more source

Severe Impact of Omeprazole Timing on pH‐Sensitive Dasatinib Absorption: Unveiling Substantial Drug–Drug Interaction

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract The absorption and bioavailability of most tyrosine kinase inhibitors are affected by gastrointestinal pH as they are weak basic lipophilic drugs. Hence, concomitant use of acid reducing agents (ARAs) is frequently restricted. Particularly comedication of crystalline dasatinib (Sprycel) and proton‐pump inhibitors (PPIs) should be avoided. Drug–
Per Andersson   +4 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling and Simulation to Support a Change in the FDA‐Labeled Dosing Frequency of RHB‐105 Low‐Dose Rifabutin Triple Therapy for Helicobacter pylori Eradication

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Patient adherence is vital for Helicobacter pylori eradication. Simplifying therapy dosing schedules may promote patient adherence, enhance treatment success rates, and help mitigate the development of antibiotic resistance. We aimed to assess plasma and intragastric rifabutin, amoxicillin, and omeprazole concentrations comparing two dosing ...
Nimish Vakil   +6 more
wiley   +1 more source

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