Results 201 to 210 of about 133,728 (302)

Validation of the Milan Score Using Prolonged Wireless PH Monitoring

Alimentary Pharmacology &Therapeutics, EarlyView.
The Milan Score, a high‐resolution manometry‐derived tool, predicts pathological GERD on 96‐h wireless pH monitoring with high specificity and positive predictive value, maintaining robust discriminative performance across both typical and atypical symptom profiles and outperforming single HRM parameters as a standalone manometric parameter.
Stefano Siboni, Jiurgen Mema, Trevor McCarthy, Roberta De Maron, Matthew K. Schroeder, Marco Sozzi, Carlo Galdino Riva, Emanuele Asti, C. Prakash Gyawali   +8 more
wiley   +1 more source

Benign gastric outlet obstruction: evolving strategies from surgery to endoscopic ultrasound-guided gastrojejunostomy. [PDF]

Ther Adv Gastrointest Endosc
Rizzo GEM, Infantino G, Rancatore G, Quintini D, Ligresti D, Belluardo N, Rizzo G, D'amore E, Giacchetto M, Tarantino I.   +9 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Naloxone plus enteral nutrition for gastrointestinal dysfunction in elderly cerebral infarction and peptic ulcer patients. [PDF]

World J Gastrointest Surg
Chen XX, Han XF, Chu Y.
europepmc   +1 more source

PERFORATED PEPTIC ULCER

Annals of Surgery, 1941
R A, Griswold, R F, Antoncic
openaire   +3 more sources

Downstream Treatment Burden and Health‐Care Utilization Following Initiation of GLP‐1 Receptor Agonists or SGLT2 Inhibitors in Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and sodium–glucose cotransporter 2 (SGLT2) inhibitors are widely used for the treatment of type 2 diabetes, yet their downstream consequences in routine clinical practice remain incompletely characterized.
Yazan Alhamdan, Jason C. Hsu, Christine Y. Lu   +2 more
wiley   +1 more source

Endoscopic balloon dilation for peptic gastroduodenal stenosis with gastric outflow obstruction: effectiveness, durability and early predictors of unsatisfactory outcomes. [PDF]

BMC Gastroenterol
Zeyara A, Scarfone L, Jeremiasen M, Falkenback D, Andersson B, Tingstedt B, Johansson J.   +6 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

In Silico and Wet Analysis of BAX Gene G-248A Polymorphism and mRNA Expression in Peptic Ulcer Disease and Gastric Cancer. [PDF]

Curr Issues Mol Biol
Żebrowska-Nawrocka M, Świechowski R, Szmajda-Krygier D, Lenda B, Mirowski M, Czaplij M, Balcerczak M, Balcerczak E.   +7 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source