Results 271 to 280 of about 157,821 (337)

Relative efficacy of GLP‐1 and GLP‐1/GIP receptor agonists in the prevention of alcohol‐use disorders using a target trial emulation approach

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims There is growing evidence that the GLP‐1 system is implicated in alcohol and other substance use disorders, and that GLP‐1‐based therapies may have therapeutic relevance in alcohol use disorder (AUD). We aimed to determine the impact of GLP‐1 based therapies on incident AUDs in a real‐world setting in patients with T2D.
Alex E. Henney, David R. Riley, Megan Heague, Carl A. Roberts, Theresa J. Hydes, Matthew Anson, David M. Hughes, Uazman Alam, Daniel J. Cuthbertson   +8 more
wiley   +1 more source

Characteristics, therapeutic pathway and the economic burden of patients with drug‐resistant epilepsy: A real‐world analysis following the introduction of cenobamate in Italy

Epilepsia, EarlyView.
Abstract Objectives Drug‐resistant epilepsy (DRE) remains a major clinical challenge, affecting approximately one‐third of patients with epilepsy. Cenobamate, a novel antiseizure medication (ASM) approved in Italy in 2022, has shown promise in clinical trials. However, real‐world data on its use, especially economic evaluations, remain limited.
Valentina Perrone, Chiara Veronesi, Maria Cappuccilli, Margherita Andretta, Marcello Bacca, Antonietta Barbieri, Fausto Bartolini, Alessandro Brega, Maria Rosaria Cillo, Francesco Colasuonno, Stefania Dell'Orco, Fulvio Ferrante, Stefano Grego, Antonella Lavalle, Daniela Mancini, Maurizio Pastorello, Romina Pagliaro, Cataldo Procacci, Camilla Scandolara, Patrizia Schiavone, Loredana Ubertazzo, Paola Valpondi, Adriano Vercellone, Alberto Zucchi, Maria Ciappetta, Domenico Lucatelli, Andrea Cinti Luciani, Luca Degli Esposti   +27 more
wiley   +1 more source

Prevalence and patterns of multiple long-term conditions among lymphatic filariasis patients in Odisha, India: a community-based cross-sectional study. [PDF]

BMC Public Health
Sinha A, Sahoo PK, Sahoo KC, Highton P, Mohanty S, Nayak T, Prusty AK, Choudhury S, Kumari B, Puchner K, Khunti K, Pati S.   +11 more
europepmc   +1 more source

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, EarlyView.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

Pancreas-sparing duodenectomy for kissing duodenal ulcers spawned by refractory peptic ulcer disease: case report with technical note and literature review. [PDF]

J Surg Case Rep
Giungato S, Lozito C, Palazzo R, Dimito C, Pepe AS.   +4 more
europepmc   +1 more source

Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin

The FEBS Journal, EarlyView.
We characterize the PLTL lectin from Photorhabdus laumondii, which adopts a unique TNF‐like fold. Binding assays reveal a preference for branched histo‐blood group oligosaccharides. Protein crystallography uncovers a novel hexameric assembly and identifies key residues involved in carbohydrate recognition.
Filip Melicher, Pavel Dobeš, Jan Komárek, Lukáš Faltinek, Marek Korsák, Petra Sýkorová, Josef Houser, Michaela Wimmerová   +7 more
wiley   +1 more source

Low Cholesterol Concentrations and the Risk of Peptic Ulcer Bleeding: A Retrospective Cohort Study. [PDF]

J Clin Med
Kök M, Dolu S, Arayici ME, Köker G, Koç LZ, Cekin AH.   +5 more
europepmc   +1 more source

Morbidity and risk factors of COVID‐19 in people with HIV‐1 in Europe: A combined observational cohort and nested case–control study

HIV Medicine, EarlyView.
Abstract Objective To study the COVID‐19 disease course in people living with HIV (PLWH) based on meaningful case numbers, information about comorbidities, antiretroviral and COVID‐19 treatment and HIV disease‐related variables. Methods Multi‐centre, observational, retrospective study of people living with HIV with COVID‐19 matched to HIV‐uninfected ...
Georg M. N. Behrens, Lambert Assoumou, Stephane De Wit, Rona MacDonald, Nathalie de Castro, Casper Rokx, Holly Middleditch, Margaret Johnson, Jose Luis Casado, Jose Ramon Arribas, Jose‐Ramon Blanco, Carl Fletcher, Caroline Eteve‐Pitsaer, Aliou Baldé, Anton Pozniak, Esteban Martinez, on behalf of the HIV CoCo Study Group, Arkaitz Imaz, David Rial Crestelo, Mar Masia Canuto, Jose Luis Blanco Arevalo, Alberto Díaz De Santiago, Pere Domingo Pedrol, Patrick Philibert, Jean‐Michel Molina, Frank Post, Ade Apoola, Chloe Orkin, Mark Gompels, Margherita Bracchi, Julie Fox, Marta Vasylyev   +31 more
wiley   +1 more source

Benign Duodenocolic Fistula: A Rare Complication of Peptic Ulcer Disease. [PDF]

Eur J Case Rep Intern Med
Cahoon AF, Tou LC, Adenote AT, Triplett DJ, Musleh M.   +4 more
europepmc   +1 more source

Sustainable bioceramics, biopolymers, and composites for bone applications: From bench to production

International Journal of Applied Ceramic Technology, EarlyView.
Abstract In response to environmental challenges and primary resource scarcity, sustainable approaches that rely on recycling and reusing waste materials are becoming highly valuable and appealing options in modern society. These strategies have started being applied in biomaterials science, too, leading to the advent of new synergies between ...
Bohan Zhang, Francesco Baino
wiley   +1 more source