Results 111 to 120 of about 3,746,064 (390)

The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]

, 2011
Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman, Chaim Gilon, Galila Agam, Itshak Levi, Joseph Fanous, Miriam Eisenstein, Orna Almog, Yael Askira, Yftah Talgan   +8 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Lectin-mediated reversible immobilization of human cells into a glycosylated macroporous protein hydrogel as a cell culture matrix

Scientific Reports, 2017
3D cell culture is a helpful approach to study cell-cell interaction in a native-like environment, but is often limited due the challenge of retrieving cells from the material.
Nicholas Bodenberger, Dennis Kubiczek, Laura Trösch, Ali Gawanbacht, Susanne Wilhelm, Denis Tielker, Frank Rosenau   +6 more
doaj   +1 more source

TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide–HLA Complex [PDF]

, 2020
C.H. Coles, Rachel M. Mulvaney, S. Malla, Andrew Walker, Kathrine J. Smith, Angharad Lloyd, Kate L. Lowe, Michelle L. McCully, Ruth Martinez Hague, Milos Aleksic, Jane Harper, Samantha Paston, Zoe Donnellan, F. Chester, Katrin Wiederhold, R.A. Robinson, Andrew Knox, Andrea Stacey, Joseph Dukes, Emma Baston, Sue Griffin, Bent K. Jakobsen, Annelise Vuidepot, Stephen Harper   +23 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production.

Journal of Organic Chemistry, 2019
In recent years, there has been a growing interest in therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 in clinical trials, and >200 in preclinical development.
Albert Isidro-Llobet, Martin N. Kenworthy, Subha Mukherjee, M. Kopach, K. Wegner, F. Gallou, Austin G. Smith, F. Roschangar   +7 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma

Cell Death and Disease
Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options.
Jiabing Li, Xiaorong Feng, Zhaohui Liu, Yunfang Deng, Zhiming Sun, Bei Chen, Lihui Wu, Xiaolong Wang, Lin Miao, Liyuan Zeng, Lei Hu, Yuming He, Ying Sheng, Yue Liu, Yu Zhao   +14 more
doaj   +1 more source

Formulation and Biological Evaluation of Mesoporous Silica Nanoparticles Loaded with Combinations of Sortase A Inhibitors and Antimicrobial Peptides [PDF]

, 2022
Sitah Alharthi, Zyta M. Ziora, Taskeen Iqbal Janjua, Amirali Popat, Peter M. Moyle   +4 more
openalex   +1 more source

Antimicrobial peptides

Upsala Journal of Medical Sciences, 2014
With increasing antibiotics resistance, there is an urgent need for novel infection therapeutics. Since antimicrobial peptides provide opportunities for this, identification and optimization of such peptides have attracted much interest during recent years.
openaire   +2 more sources